Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Preparation of anti-tumor nanoparticles using tiger milk mushroom

07.08.2012
Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough from HKPolyU uses tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

Cancer is a word dreaded by many. Many cancers are deadly and difficult to treat while conventional remedies such as chemotherapy often cause physical and emotional sides effects, giving struggling patients more harm just as the cancer. What if cancer-killing drugs can become more natural and in harmony with our body?


A polysaccharide-protein complex was found in Tiger Milk mushrooms from Africa, which can turn selenium into new cancer treatment

Copyright : Hong Kong Polytechnic University

Tapping into the power of natural ingredients for safer treatment is the next frontier in the battle against cancer. A recent breakthrough from PolyU’s Department of Applied Biology and Chemical Technology using tiger milk mushroom to prepare anti-tumor nanoparticles is bringing us one step closer.

A natural compound found in mushrooms may hold the key to a new class of cancer drugs. In Tiger Milk mushrooms from Africa, Dr Wong Ka-hing, Associate Director of the Food Safety and Technology Research Centre, has discovered a polysaccharide-protein complex (PSP) which can turn selenium, a common nutrient, into new cancer therapy to benefit millions of breast cancer patients around the world.

Selenium is a trace mineral essential for good health. Health benefits include boosting immune systems against viral infections. Staple foods and vegetables in our diet such as rice, wheat, potatoes, broccolis and onions are great sources of antioxidant. In nano-size, selenium was found to have potent anti-cancer effect in the laboratory. However, efficacy diminished as the nanoparticles fell back into bigger aggregates which suppressed the up-take into cancer cells. Finding new ways or compounds to halt the rebinding process is harder than it seems. Literally, it is quite like searching for a needle in a haystack.

The use of mushroom PSP as stabilizing force is a significant breakthrough. Combined with cutting-edge nanotechnology, Dr Wong and his team successfully made selenium nanoparticles to destroy breast cancer cells. “Lab-test results were exciting. Our selenium nanoparticles were found to have remarkable inhibition effect on the growth of human breast cancer cells by triggering the cells into self-destruction. The next stage will be tests on animals,” Dr Wong said.

The research is still in a very early phase. But if successful, it could lead to a new drug much less toxic and more reliable, capable of killing cancer cells while leaving healthy tissues unharmed, which could mean fewer agonizing side-effects, greater comfort and better chances of recovery. Dr Wong also planned on developing a dietary supplement as auxiliary cancer treatments.

Scientists around the world have been looking into the therapeutic value of produces such as fish oil, broccoli, cauliflower, cabbage, and green tea. For safe human consumption, a natural ingredient must be effective against cancer in low concentration. Dr Wong’s work has advanced medicine with a working tool for boosting the effectiveness of natural cancer killing compounds.

“Mushroom PSP has striking effects on controlling selenium nanoparticles,” Dr. Wong added, “and a better understanding of this mechanism may help us find the next suitable compounds and make better nano-medicines for a whole host of cancers.” Tiger Milk, similar to Chinese mushrooms we have in dishes and soups mushroom, is a common foodstuff in Africa, and the groundbreaking biomedical research opens door to making cancer drug from 100% natural ingredients. The drug development process is equally natural and green because all it takes are room temperature and water, which is little waste and without much power consumption.

Holding new promise for beating cancer, this research has won Dr Wong the Young Investigator Award at the 2011 International Conference of Food Factors and the Gold Medal in 40th International Exhibition of Inventions of Geneva. These prestigious awards were at the same time an endorsement to the long-running commitment from the University to the discovery and development of ingredients for the betterment of the community.

Wilfred Lai | Research asia research news
Further information:
http://www.pdo.polyu.edu.hk/en/technology_frontier.asp?ID=92
http://www.researchsea.com

More articles from Life Sciences:

nachricht Biophysicists reveal how optogenetic tool works
29.05.2020 | Moscow Institute of Physics and Technology

nachricht Mapping immune cells in brain tumors
29.05.2020 | University of Zurich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Biotechnology: Triggered by light, a novel way to switch on an enzyme

In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".

Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

Black nitrogen: Bayreuth researchers discover new high-pressure material and solve a puzzle of the periodic table

29.05.2020 | Materials Sciences

Argonne researchers create active material out of microscopic spinning particles

29.05.2020 | Materials Sciences

Smart windows that self-illuminate on rainy days

29.05.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>