Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obstacles to stem cell therapy cleared

10.06.2010
Researchers at Lund University have come up with a new technique to prevent tumours developing in connection with stem cell transplantations. The results have been published today in the respected scientific journal PNAS.

“When you develop, for example, nerve cells for transplantation, you always get a small contamination of immature stem cells”, explains Johan Jakobsson, head of research group at the Department of Experimental Medical Science.

These immature stem cells can lead to tumours – an unacceptable side-effect.
“We have developed a technique that enables us to eliminate immature stem cells and thus create safer stem cell transplantations.”

The researchers have transplanted the stem cells into mice with Parkinson’s disease. The results are very promising: there are far fewer tumours and the cells that survive are the correct type of nerve cells. The technique uses a specially designed virus.

“We use the virus to genetically modify the cells, which means that we can see which ones we want and which ones we don’t want. You could say that we hijack one of the cell’s gene regulation systems, microRNA. The cell itself tells us when it is mature; it is black when it is immature and turns green when it has completed its development.”

It is relatively simple to isolate, cultivate, preserve and genetically modify stem cells. If transplanted into humans they could replace damaged tissue in the nervous system and support other cells that work to heal a brain injury.

“For us this is a major step. Previously tumours have always developed with this type of transplantation. Now we have shown that this can be avoided”, says Johan Jakobsson.

At Lund University collaborations are underway on stem cell therapy, for example, for Parkinson’s disease, diabetes, stroke, leukaemia and breast cancer. The research community has set the goal of making stem-cell based treatment effective and safe for at least one of the diseases within the next 10 years.

“Our technique could in theory be used for all these diseases”, says Johan Jakobsson. The next step is to conduct experiments on human cell lines.

This project is a collaboration within the Bagadilico research network.

Johan Jakobsson; johan.jakobsson@med.lu.se;
Tel: +46 (0)46 222 42 25; Mobile work: +46 (0)709 28 64 43
Tillbaka

Megan Grindley | idw
Further information:
http://www.pnas.org/content/early/2010/06/03/1006568107.abstract
http://www.med.lu.se/bagadilico

More articles from Life Sciences:

nachricht Chip-based optical sensor detects cancer biomarker in urine
06.12.2019 | The Optical Society

nachricht Scientist identify new marker for insecticide resistance in malaria mosquitoes
06.12.2019 | Liverpool School of Tropical Medicine

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing a digital twin

University of Texas and MIT researchers create virtual UAVs that can predict vehicle health, enable autonomous decision-making

In the not too distant future, we can expect to see our skies filled with unmanned aerial vehicles (UAVs) delivering packages, maybe even people, from location...

Im Focus: The coldest reaction

With ultracold chemistry, researchers get a first look at exactly what happens during a chemical reaction

The coldest chemical reaction in the known universe took place in what appears to be a chaotic mess of lasers. The appearance deceives: Deep within that...

Im Focus: How do scars form? Fascia function as a repository of mobile scar tissue

Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix. Until today, the question about the exact anatomical origin of these fibroblasts has not been answered. In order to find potential ways of influencing the scarring process, the team of Dr. Yuval Rinkevich, Group Leader for Regenerative Biology at the Institute of Lung Biology and Disease at Helmholtz Zentrum München, aimed to finally find an answer. As it was already known that all scars derive from a fibroblast lineage expressing the Engrailed-1 gene - a lineage not only present in skin, but also in fascia - the researchers intentionally tried to understand whether or not fascia might be the origin of fibroblasts.

Fibroblasts kit - ready to heal wounds

Im Focus: McMaster researcher warns plastic pollution in Great Lakes growing concern to ecosystem

Research from a leading international expert on the health of the Great Lakes suggests that the growing intensity and scale of pollution from plastics poses serious risks to human health and will continue to have profound consequences on the ecosystem.

In an article published this month in the Journal of Waste Resources and Recycling, Gail Krantzberg, a professor in the Booth School of Engineering Practice...

Im Focus: Machine learning microscope adapts lighting to improve diagnosis

Prototype microscope teaches itself the best illumination settings for diagnosing malaria

Engineers at Duke University have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The Future of Work

03.12.2019 | Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

 
Latest News

Solving the mystery of carbon on ocean floor

06.12.2019 | Earth Sciences

Chip-based optical sensor detects cancer biomarker in urine

06.12.2019 | Life Sciences

A platform for stable quantum computing, a playground for exotic physics

06.12.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>