Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nutrigenomics Researchers Replicate Gene Interaction With Saturated Fat

18.11.2009
Tufts University researchers have identified a gene-diet interaction that appears to influence body weight and have replicated their findings in three independent studies.

Men and women carrying the CC genotype demonstrated higher body mass index (BMI) scores and a higher incidence of obesity, but only if they consumed a diet high in saturated fat. These associations were seen in the apolipoprotein A-II gene (APOA2) promoter.

“We believe this is the first time a gene-diet interaction influencing BMI and obesity has been replicated in as many as three independent study populations,” said corresponding and senior author Jose Ordovas, PhD, director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts. “Our findings strengthen support for the science of nutrigenomics and are another step toward the goal of individually tailoring dietary recommendations to lower risk of chronic disease or conditions like obesity.”

The study, published in the November 9 issue of Archives of Internal Medicine, examines gene-diet interactions in the APOA2 promoter, a region of DNA controlling expression of the APOA2 gene. Proteins responding to some nutrients in food interact with promoters which dictate how genes behave. There are two variants or alleles of the APOA2 promoter, T and C. They exist in three genotypes: CC, TT and TC.

Ordovas and colleagues studied these genotypes in 3,462 men and women who participated in the Framingham Offspring Study (FOS), the Genetics of Lipid Lowering Drugs and Diet Network Study (GOLDN) and the Boston-Puerto Rican Centers on Population and Health Disparities Study (Boston-Puerto Rican Study). FOS and GOLDN enrolled Caucasian adults. The Boston-Puerto Rican Study is comprised of Puerto Rican men and women. “We are further encouraged that our findings were replicated in diverse populations,” said Ordovas, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts.

The researchers divided the study population into high and low saturated fat groups. Next, they compared saturated fat intake, BMI and obesity risk across the CC, TT and TC genotypes. High-saturated fat intake was defined as 22 grams or more per day. Foods such as fatty cuts of meat and dairy products made with whole or 2 % milk contain saturated fat, which raises cholesterol. CC carriers who consumed high levels of saturated fat were the most susceptible to higher BMI and obesity, Ordovas and colleagues observed.

“Across all three studies, the CC carriers who consumed high-saturated fat diets had the highest BMIs compared to the TT and TC genotypes and, most notably, other CC carriers who reported consuming low-saturated fat diets,” said first author Dolores Corella, PhD, professor at the Valencia University-CIBER Fisiopatología de la Obesidad y Nutrición (Spain) and visiting scientist in the Nutrition and Genomics Laboratory at the USDA HNRCA. “This work is based on a two year-old study finding genotypes influence food preferences, calorie intake and BMI.”

In the previous study, Ordovas, Corella and colleagues found men and women with the CC genotype had a statistically significant higher intake of fat than the TT and TC genotype groups. Additionally, CC carriers ate about 200 more calories per day and were about twice as likely to be obese.

The authors saw the same results for obesity prevalence within the CC genotype in the present study. “We saw a strong association between obesity and high-saturated fat intake, but again, there was no significant association between the two in CC carriers with low-saturated fat intake or in TT or TC carriers,” Corella added.

Obesity was defined as BMI of 30 or greater. The researchers calculated BMI as weight in kilograms divided by height in meters squared. Dietary intake was measured by self-reported dietary questionnaires.

As in the general population, the majority of study participants possessed the TT and TC genotypes. Approximately 10 to 15 percent of the United States population is CC carriers, which was reflected in the FOS, GOLDN and Boston Puerto-Rican Study.

“Although CC carriers are only a small portion of the population, we believe the interaction we observed between saturated fat and BMI merits further investigation,” Ordovas said. “There is a need to understand the mechanisms behind this particular diet-gene interaction and to find out whether other there are similar interactions in other genes that could factor in obesity prevention.”

This work was funded by the National Institute of Diabetes and Digestive and Kidney Diseases, National Heart, Lung and Blood Institute, National Institute on Aging, the USDA Agriculture Research Service (ARS), the Ministerio de Ciencia e Innovacion, the Instituto de Salud Carlos III and the CIBER Fisiopatología de la Obesidad y Nutrición, Madrid, Spain.

Corella D, Peloso G, Arnett DK, Demissie S, Cupples LA, Tucker K, Lai C, Parnell LD, Coltell O, Lee Y and Ordovas JM. Arch Intern Med . (Nov. 9, 2009); vol. 169 (20): 1897-1906. “APOA2, Dietary Fat and Body Mass Index.”

About Tufts University School of Nutrition

The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University is the only independent school of nutrition in the United States. The school's eight centers, which focus on questions relating to famine, hunger, poverty, and communications, are renowned for the application of scientific research to national and international policy. For two decades, the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University has studied the relationship between good nutrition and good health in aging populations. Tufts research scientists work with federal agencies to establish the USDA Dietary Guidelines, the Dietary Reference Intakes, and other significant public policies.

Andrea Grossman | Newswise Science News
Further information:
http://www.tufts.edu

More articles from Life Sciences:

nachricht Nonstop Tranport of Cargo in Nanomachines
20.11.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik

nachricht Researchers find social cultures in chimpanzees
20.11.2018 | Universität Leipzig

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nonstop Tranport of Cargo in Nanomachines

Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.

Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

Nonstop Tranport of Cargo in Nanomachines

20.11.2018 | Life Sciences

Researchers find social cultures in chimpanzees

20.11.2018 | Life Sciences

When AI and optoelectronics meet: Researchers take control of light properties

20.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>