Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Noninvasive measurement enables use of IFP as potential biomarker for tumor aggressiveness

01.10.2012
Researchers validated a method of noninvasive imaging that provides valuable information about interstitial fluid pressure of solid tumors and may aid in the identification of aggressive tumors, according to the results of a study published in Cancer Research, a journal of the American Association for Cancer Research.

Many malignant solid tumors generally develop a higher interstitial fluid pressure (IFP) than normal tissue. High IFP in tumors may cause a reduced uptake of chemotherapeutic agents and resistance to radiation therapy. In addition, a high IFP has been found to promote metastatic spread.

"Currently, an imaging method for noninvasive assessment of the IFP of tumors is needed to evaluate the potential of IFP as a biomarker for cancer aggressiveness and, hence, to identify patients with cancer who may benefit from particularly aggressive treatment because of highly elevated tumor IFP," said Einar K. Rofstad, Ph.D., of the department of radiation biology at the Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway.

Rofstad and colleagues tested the use of dynamic contrast-enhanced magnetic resonance imaging (MRI) to evaluate the velocity of fluid flow from tumors in human cell lines of cervical carcinoma and melanoma implanted in mice. Researchers hypothesized that the velocity of fluid flow from tumor tissue into adjacent tissue was determined by the IFP drop at the tumor surface.

Results indicated that the velocity of the fluid flow at the tumor surface strongly correlated with the magnitude of the tumor IFP and that dynamic contrast-enhanced MRI with gadolinium diethylene-triamine penta-acetic acid (Gd-DTPA) as a contrast agent can be used to noninvasively measure the fluid-flow velocity. In addition, primary tumors of mice with metastases had a significantly higher IFP and fluid-flow velocity at the tumor surface compared with the primary tumors of metastasis-free mice, confirming that the development of lymph node metastases strongly correlated to the IFP of the primary tumor and the velocity of fluid flow as measured by Gd-DTPA-based dynamic contrast-enhanced MRI.

"Our findings establish that Gd-DTPA-based dynamic contrast-enhanced MRI can noninvasively visualize tumor IFP," Rofstad said. "This reveals the potential for the fluid-flow velocity at the tumor surface determined by this imaging method to serve as a novel general biomarker of tumor aggressiveness."

Rofstad said that comprehensive prospective clinical investigations in several types of cancer are needed to assess the value of fluid-flow velocity at the tumor surface level assessed by Gd-DTPA-based dynamic contrast-enhanced MRI as a general biomarker for interstitial hypertension-induced cancer aggressiveness.

Follow the AACR on Twitter: @aacr #aacr

Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the AACR

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR's membership includes 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of individual and team science grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.

For more information about the AACR, visit www.AACR.org.

Jeremy Moore | EurekAlert!
Further information:
http://www.aacr.org

More articles from Life Sciences:

nachricht Velcro for human cells
16.01.2019 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht More efficient solar cells imitate photosynthesis
16.01.2019 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Flying Optical Cats for Quantum Communication

Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.

In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...

Im Focus: Nanocellulose for novel implants: Ears from the 3D-printer

Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.

It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:

Im Focus: Elucidating the Atomic Mechanism of Superlubricity

The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.

One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...

Im Focus: Mission completed – EU partners successfully test new technologies for space robots in Morocco

Just in time for Christmas, a Mars-analogue mission in Morocco, coordinated by the Robotics Innovation Center of the German Research Center for Artificial Intelligence (DFKI) as part of the SRC project FACILITATORS, has been successfully completed. SRC, the Strategic Research Cluster on Space Robotics Technologies, is a program of the European Union to support research and development in space technologies. From mid-November to mid-December 2018, a team of more than 30 scientists from 11 countries tested technologies for future exploration of Mars and Moon in the desert of the Maghreb state.

Close to the border with Algeria, the Erfoud region in Morocco – known to tourists for its impressive sand dunes – offered ideal conditions for the four-week...

Im Focus: Programming light on a chip

Research opens doors in photonic quantum information processing, optical signal processing and microwave photonics

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a new integrated photonics platform that can...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Our digital society in 2040

16.01.2019 | Event News

11th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Aachen, 3-4 April 2019

14.01.2019 | Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

 
Latest News

Velcro for human cells

16.01.2019 | Life Sciences

Kiel physicists discover new effect in the interaction of plasmas with solids

16.01.2019 | Physics and Astronomy

The pace at which the world’s permafrost soils are warming

16.01.2019 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>