Scientists from the Schuman Lab at the Max Planck Institute for Brain Research have investigated the variety of structures and functions in non-coding parts of messenger RNA (mRNA) from brain cells. These untranslated regions (UTRs) are essential for regulating the stability and localization of mRNAs, as well as its translation into proteins. The scientists will report their findings in the latest edition of Neuron.
Our brain’s capacity to learn and to form memories relies on the ability to respond adaptively to environmental inputs. The integration of these inputs occurs at synapses, the connections between brain cells.
Unlike other cell types in the body, neurons have an elaborate architecture, consisting of axons to transmit and dendrites to receive information. Like all cells, neurons use proteins to carry out their important cellular functions. Neurons supply their processes with proteins by moving mRNA molecules to the dendrites and axons where they can be locally translated.
A mRNA molecule consists of a coding sequence in the middle, which serves as a template for new proteins, and two non-coding regions located on both ends: the 3’ region on the right and 5’ on the left hand side. These so-called untranslated regions (UTRs) control gene expression at the RNA level and are variable in length and composition. By acting as binding platforms, they can regulate stability, trafficking and translation, thus dictating the fate of an mRNA molecule within a cell.
Researchers from the Schuman Lab now sequenced the mRNA present in different regions of rat hippocampal slices and took a closer look at the 3’ UTR region. Schuman: “When we examined mRNA in both neuronal cell bodies and in the neuropil, primarily consisting of axons and dendrites, we noticed a huge diversity in the 3’UTRs of neuronal mRNAs with many transcripts showing enrichment for a particular 3’UTR isoform in a cellular compartment.
In addition, the isoforms enriched in the neuropil proved to be more stable than those located in the cell body.” The scientists were even able to follow the dynamics of these molecules during a period of enhanced neural activity and observed an alteration of 3’UTR isoforms present in each compartment. The Schuman team speculates that some of the changes in the dendritic compartment might be due to local remodeling of 3’UTRs.
Publication: Tushev, G., Glock, C., Heumueller, M., Biever, A., Jovanovic, M. and Schuman, E.M. (2018). Alternative 3’UTRs modify the localization, regulatory potentia l, stability, and plasticity of mRNAs in neuronal compartments. Neuron, in press.
Dr. Arjan Vink | Max-Planck-Institut für Hirnforschung
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences