Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Next-generation glaucoma therapeutics hold considerable promise

08.04.2014

Elevated pressure in the eye is the most common risk factor for glaucoma, an optic neuropathy that can cause blindness and affects more than 67 million people worldwide.

Elevated eye pressure in glaucoma develops due to abnormal functioning of the trabecular meshwork (TM) causing intraocular fluid to back up. Next-generation glaucoma drugs will target the finely tuned mechanisms of the TM that maintain normal intraocular pressure, as described in an article in Journal of Ocular Pharmacology and Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article, one of 25 articles in a special double issue of the Journal, is available free on the Journal of Ocular Pharmacology and Therapeutics website.


Celebrating 30 years in 2014, Journal of Ocular Pharmacology and Therapeutics is an authoritative peer-reviewed journal published ten times a year online with Open Access options and in print. It is the only multidisciplinary, peer-reviewed journal providing basic and clinical research that focuses on biopharmaceuticals that have the potential to prevent, treat, and/or diagnose ocular diseases and disorders. The Journal delivers the latest discoveries in the pharmacokinetics and pharmacodynamics of biopharmaceuticals for the treatment of ophthalmic disorders. Journal of Ocular Pharmacology and Therapeutics is the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Complete tables of content and a sample issue may be viewed on the Journal of Ocular Pharmacology and Therapeutics website.

Credit: © Mary Ann Liebert, Inc., publishers

The article "Intraocular Pressure Homeostasis: Maintaining Balance in a High-Pressure Environment," by Ted Acott and coauthors, Oregon Health & Science University, Portland, OR, describes the efficient mechanisms at work in the eye to keep intraocular pressure within an acceptable range for 92-98% of the population. Understanding these mechanisms will enable the development of drug interventions to treat the unfortunate 2-8% of people that are at risk of developing elevated eye pressure and glaucoma.

"The TM, a unique multilayered tissue that controls intraocular pressure, and its surrounding structures represent viable targets for the development of novel glaucoma therapies," write Editor-in-Chief W. Daniel Stamer, PhD, Duke University (Durham, NC) and Guest Editor John R. Samples, MD, Professor, Rocky Vista University and Director, Western Glaucoma Foundation, Portland, OR, in the Editorial "The Trabecular Meshwork Special Issue, Inspired by the TM Study Club."

The special double issue provides a comprehensive look at the TM and next-generation glaucoma therapies in development through a collection of editorials, original research articles, and reviews. Included is the review article "The Role of TGF-ß2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma," in which Robert Wordinger, Tasneem Sharma, and Abbot Clark, University of North Texas Health Science Center, Fort Worth, describe the TGF-ß superfamily of growth factors and their role in primary open-angle glaucoma (POAG), the second leading cause of blindness worldwide.

Also of note, Nelson Winkler, Mayo Clinic College of Medicine, and Michael Fautsch, Mayo Clinic, Rochester, MN, explore the current understanding of how prostaglandin analogues, first-line treatments for glaucoma, work to reduce elevated intraocular pressure, in the review article "Effects of Prostaglandin Analogues on Aqueous Humor Outflow Pathways."

###

About the Journal

Celebrating 30 years in 2014, Journal of Ocular Pharmacology and Therapeutics is an authoritative peer-reviewed journal published ten times a year online with Open Access options and in print. It is the only multidisciplinary, peer-reviewed journal providing basic and clinical research that focuses on biopharmaceuticals that have the potential to prevent, treat, and/or diagnose ocular diseases and disorders. The Journal delivers the latest discoveries in the pharmacokinetics and pharmacodynamics of biopharmaceuticals for the treatment of ophthalmic disorders. Journal of Ocular Pharmacology and Therapeutics is the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Complete tables of content and a sample issue may be viewed on the Journal of Ocular Pharmacology and Therapeutics website.

About the Publisher Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Assay and Drug Development Technologies and Population Health Management. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Vicki Cohn | EurekAlert!

More articles from Life Sciences:

nachricht Enzymes as double agents: new mechanism discovered in protein modification
07.07.2020 | Westfälische Wilhelms-Universität Münster

nachricht Protein linked to cancer acts as a viscous glue in cell division
07.07.2020 | Rensselaer Polytechnic Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Excitation of robust materials

Kiel physics team observed extremely fast electronic changes in real time in a special material class

In physics, they are currently the subject of intensive research; in electronics, they could enable completely new functions. So-called topological materials...

Im Focus: Electrons in the fast lane

Solar cells based on perovskite compounds could soon make electricity generation from sunlight even more efficient and cheaper. The laboratory efficiency of these perovskite solar cells already exceeds that of the well-known silicon solar cells. An international team led by Stefan Weber from the Max Planck Institute for Polymer Research (MPI-P) in Mainz has found microscopic structures in perovskite crystals that can guide the charge transport in the solar cell. Clever alignment of these "electron highways" could make perovskite solar cells even more powerful.

Solar cells convert sunlight into electricity. During this process, the electrons of the material inside the cell absorb the energy of the light....

Im Focus: The lightest electromagnetic shielding material in the world

Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.

Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...

Im Focus: Gentle wall contact – the right scenario for a fusion power plant

Quasi-continuous power exhaust developed as a wall-friendly method on ASDEX Upgrade

A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...

Im Focus: ILA Goes Digital – Automation & Production Technology for Adaptable Aircraft Production

Live event – July 1, 2020 - 11:00 to 11:45 (CET)
"Automation in Aerospace Industry @ Fraunhofer IFAM"

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM l Stade is presenting its forward-looking R&D portfolio for the first time at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

International conference QuApps shows status quo of quantum technology

02.07.2020 | Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

 
Latest News

Guido Bonati is the new Chief Technology Officer and Head of Research & Development at FISBA AG

08.07.2020 | Press release

Quick notes in the genome

07.07.2020 | Life Sciences

Limitations of Super-Resolution Microscopy Overcome

07.07.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>