A popular model suggests life on Earth began with RNA. A recent study reveals how RNA precursors can arise from complex chemical networks that evolve from simple chemicals, providing new directions for testing how RNA might form on primitive planets.
Chemists have long sought to understand the origins of life, with one popular model suggesting life began when simple RNA molecules capable of copying themselves formed spontaneously in the primitive environment. How this happened exactly is fraught with difficulties.
New research by a team of chemists led by Ruiqin Yi of the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology and Albert Fahrenbach, a lecturer at the University of New South Wales, suggests that mixtures of simple organic compounds in water exposed to high energy radiation react to form a variety of more complex organic compounds that could help make RNA. Researchers from the Institute for Advanced Study in Princeton, Tokyo Tech and the University of Arizona also assisted in the work.
To conduct this work, the team took a mixture of very simple small molecules, common table salt, ammonia, phosphate and hydrogen cyanide, and exposed them to a high energy gamma radiation source at Tokyo Tech. These conditions simulate environments irradiated by naturally occurring radioactive minerals, which were likely much more prevalent on early Earth.
They also allowed their reactions to intermittently dry down, simulating evaporation in shallow puddles and beaches. Their reactions surprisingly made a variety of compounds which might have been important for the origins of life, including precursors for amino acids and other small compounds known to be useful for making RNA.
They showed that this set of conditions creates what they call a 'continuous reaction network', in which a wide variety of compounds are constantly being formed and destroyed, and these react with each other to form new compounds. These continuous reaction networks make up a complex set of reactions, and because of the way they occur, they can make a whole set of important compounds at once.
The team thinks this makes their study especially insightful, as prebiotic chemistry on the primitive Earth could not have been as selective and goal-directed as modern organic chemists working in the lab, who can add chemicals at precisely the right time and purify the exact compounds they want to make.
The team thinks models of this type can help explain what sorts of environments are most amenable to making RNA in primitive planetary settings. Indeed, since the surfaces of rocky planets are so variable (think cool mountain streams, bubbling hot springs and sunny beaches), there are many places where such chemistry might happen, only under slightly different conditions. These studies in turn could help other scientists identify the best areas to look for life beyond Earth.
As lead author Ruiqin Yi says, 'While we haven't yet made RNA, this work raises new questions. Can we tweak these reactions to make all of the necessary building blocks for RNA from such mixtures in a continuous fashion? Can we generate other useful compounds such as more complex amino acids in this "messy" chemistry from complex chemical reaction networks?'
Ruiqin Yi1, Quoc Phuong Tran2, Sarfaraz Ali2, Isao Yoda3, Zachary R. Adam4,5, H. James Cleaves II1,5,6, and Albert C. Fahrenbach2*, A Continuous Reaction Network that Produces RNA Precursors, Proceedings of the National Academy of Sciences, DOI:10.1073/pnas.1922139117
Tokyo Institute of Technology (Tokyo Tech) stands at the forefront of research and higher education as the leading university for science and technology in Japan. Tokyo Tech researchers excel in fields ranging from materials science to biology, computer science, and physics. Founded in 1881, Tokyo Tech hosts over 10,000 undergraduate and graduate students per year, who develop into scientific leaders and some of the most sought-after engineers in industry. Embodying the Japanese philosophy of "monotsukuri," meaning "technical ingenuity and innovation," the Tokyo Tech community strives to contribute to society through high-impact research.
The Earth-Life Science Institute (ELSI) is one of Japan's ambitious World Premiere International research centers, whose aim is to achieve progress in broadly inter-disciplinary scientific areas by inspiring the world's greatest minds to come to Japan and collaborate on the most challenging scientific problems. ELSI's primary aim is to address the origin and co-evolution of the Earth and life.
The World Premier International Research Center Initiative (WPI) was launched in 2007 by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) to help build globally visible research centers in Japan. These institutes promote high research standards and outstanding research environments that attract frontline researchers from around the world. These centers are highly autonomous, allowing them to revolutionize conventional modes of research operation and administration in Japan.
Thilina Heenatigala | EurekAlert!
Surprisingly many peculiar long introns found in brain genes
10.07.2020 | Moscow Institute of Physics and Technology
Did nerve cells evolve to talk to microbes?
10.07.2020 | Christian-Albrechts-Universität zu Kiel
New insight into the spin behavior in an exotic state of matter puts us closer to next-generation spintronic devices
Aside from the deep understanding of the natural world that quantum physics theory offers, scientists worldwide are working tirelessly to bring forth a...
Kiel physics team observed extremely fast electronic changes in real time in a special material class
In physics, they are currently the subject of intensive research; in electronics, they could enable completely new functions. So-called topological materials...
Solar cells based on perovskite compounds could soon make electricity generation from sunlight even more efficient and cheaper. The laboratory efficiency of these perovskite solar cells already exceeds that of the well-known silicon solar cells. An international team led by Stefan Weber from the Max Planck Institute for Polymer Research (MPI-P) in Mainz has found microscopic structures in perovskite crystals that can guide the charge transport in the solar cell. Clever alignment of these "electron highways" could make perovskite solar cells even more powerful.
Solar cells convert sunlight into electricity. During this process, the electrons of the material inside the cell absorb the energy of the light....
Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.
Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...
A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...
07.07.2020 | Event News
02.07.2020 | Event News
19.05.2020 | Event News
10.07.2020 | Materials Sciences
10.07.2020 | Life Sciences
10.07.2020 | Materials Sciences