Adult stem cells provide the body with a reservoir from which damaged or used up tissues can be replenished. In organs like the intestines and skin, which need constant rejuvenating, these stem cells are dividing frequently. But in other body structures, including the hair follicles, they are held in a quiescent state--one in which they don't reproduce until they receive signals from their surroundings that it's time to regenerate.
It makes intuitive sense that stem cells, being such a valuable resource, would be used sparingly. Yet scientists have limited understanding of how their quiescence is regulated, and are even unsure of its precise biological function. In a study published recently in PNAS, Elaine Fuchs, Rebecca C. Lancefield Professor and head of the Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, and Kenneth Lay, a graduate student in her lab, report on new insights into the biological signals that make hair follicle stem cells oscillate between states of quiescence and regenerative activity.
"In an earlier study, my lab showed that when mice age, the old fat in their skin produces higher levels of a secreted signal, called BMP," Fuchs says. "This signal acts as a molecular brake on the hair follicle stem cells, causing them to spend much longer times in quiescence."
In the present study, Lay identified a stem cell gene that is activated by BMP signaling, and showed that when this gene is missing, the stem cells grow hairs with dramatically shorter intervals. "We thought initially that the key to hair growth might be the fountain of youth," Fuchs says, "but the mice's hair coat surprisingly thinned and greyed precociously."
More growth and fewer bulges
Usually the stem cells then create a new bulge along with the new hair, while ensuring that the old bulge and the old hair stay put in the hair follicle. Only the new bulge can make another new hair, but the old bulge is kept in place to maintain a thick and lush coat. In mice, hair follicles can accumulate up to four of these bulges.
When Lay and Fuchs created mice that lack FOXC1--by disabling or "knocking out" the gene that produces this protein--they observed that the animals' hair follicle stem cells spent more time growing hairs and less time in quiescence. Over the course of nine months, while hair follicles from normal mice grew four new hairs, those from the FOXC1 knockout mice had already made new hairs seven times. "The knockout stem cells enter an overactive state in which they can't establish quiescence adequately," explains Lay.
The researchers also found that in the absence of FOXC1, hair follicles always had only one hair despite having made new hairs seven times. This is because these hair follicles could not retain their old bulges, though they generated a new bulge without a problem. As the stem cells started proliferating more, they became less able to stick together. As a result, their old bulges did not stay properly tethered to the hair follicle when the newly growing hair pushed past it. And since the bulge emits quiescence signals, its loss activated the remaining stem cells even faster.
Going grey and going bald
While the hair follicle stem cells of FOXC1-deficient mice produce hairs at a relatively breakneck pace, this profligate growth seems to wear them out. Older knockout mice had sparser, greyer coats, and they could not regenerate their fur as quickly as their normal age-matched or younger peers. A similar phenomenon has been described in mouse hematopoietic stem cells, which give rise to blood cells--those stem cells that are more active in young animals appear to become exhausted as the animals grow older.
"Hair follicle stem cells influence the behavior of melanocyte stem cells, which co-inhabit the bulge niche," explains Fuchs. "Thus, when the numbers of hair follicle stem cells declined with age, so too did the numbers of melanocyte stem cells, resulting in premature greying of whatever hairs were left." Not much is known about naturally occurring hair loss with age, but these balding knockout mice may provide a model to study it.
Katherine Fenz | EurekAlert!
Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides
16.07.2018 | Tokyo Institute of Technology
The secret sulfate code that lets the bad Tau in
16.07.2018 | American Society for Biochemistry and Molecular Biology
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
16.07.2018 | Physics and Astronomy
16.07.2018 | Life Sciences
16.07.2018 | Earth Sciences