Botulinum toxins are currently used on more than 80 medical conditions including Muscle spasms, Overactive bladder, Chronic migraine, Cervical dystonia, Sweating and Cerebral Palsy (CP). The new toxin, Botulinum neurotoxin type X (BoNT/X), has the potential to open up a new field of toxin therapeutics related to intracellular membrane trafficking and secretion.
Since Botulinum neurotoxins are the most toxic substances known, the development of detection methods and treatments is very important.
"The discovery of BoNT/X facilitates the development of diagnostics and countermeasures which is important if someone would be exposed to a toxic amount of the substance", says Pal Stenmark, Associate Professor, Department of Biochemistry and Biophysics, Stockholm University.
The research team will now develop antibodies with the ability to detect and inactivate the toxin.
"Within a few months we will have developed ways of detecting if a person has been subject to BoNT/X", says Pal Stenmark.
The researchers will determine the structure of the toxin and investigate how it binds to the nerve cell. They will also investigate how the unique properties of BoNT/X can be best used to develop new therapeutics.
Discovered through an infant in Japan
It all started with an infant in Japan that became ill in 1995. In 2015 the genome of the bacteria isolated from the child was sequenced and deposited in a database. Hidden in the four million letter blueprint of the bacterium, the research team identified the novel toxin.
"When we first discovered this toxin I believed we had made some error in the analysis, but after checking several times it turned out to be correct. This discovery opens a multitude of new exciting research topics that we are eager to explore in collaboration with Dr. Min Dong's research team at Harvard", says Pal Stenmark.
Link to the article "Identification and characterization of a novel botulinum neurotoxin" in Nature Communications: http://www.
For further information, please contact Pal Stenmark, Associate Professor, Department of Biochemistry and Biophysics, Stockholm University, e-mail: firstname.lastname@example.org, cellphone: +46 739-84 12 16.
Annika Hallman | EurekAlert!
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences