For millions of years nature has been optimizing DNA – in all living creatures this biomolecule is responsible for storing genetic information. Now a research project supervised by Dr. Jens Müller from the Chair of Bioinorganic Chemistry at TU Dortmund, puts the long chain molecule into a new context.
Detached from its biological origin, artificial DNA double helices were modified in such a way that the evolutionarily optimized biomolecule can also be used as a key structural element for the arrangement of metal ions. There are numerous potential applications of this basic research. With this method, for example, molecular wires or the smallest magnets could be developed to be used in nanotechnology. Moreover, the scientists think about using it as catalysts, in medicine or as sensors.
In the context of the five-year project, the scientists succeeded in developing numerous so-called ”metal-ion-mediated base pairs” . By choosing the DNA sequence – the configuration of the single structural elements – the scientists can precisely influence the characteristics of the artificial “metallized” DNA. That is how, for example, the synthesis of a double helix with 19 consecutive meta-ion-mediated base pairs – the longest metal-modified DNA of this type ever reported – was done.
Within the scope of the Emmy Noether-Program, the project “Novel Metalated Base Pairs and Other Unusual DNA Motifs” has been funded with overall 530.000 Euros since August 2002. The Emmy Noether-Program is intended to support young scientists and enable them to become scientifically independent at an early stage. In this respect the Dortmund project is a total success with one habilitation thesis, two doctoral theses and five diploma theses. In addition to that, the results can be found in eleven publications in science journals.
Ole Luennemann | alfa
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Physics and Astronomy
16.11.2018 | Physics and Astronomy
16.11.2018 | Life Sciences