Because earlier studies, including Dr. Weiss', showed a protein called TERE1 or UBIAD1 is associated with an eye disease involving excess cholesterol as well as invasive prostate cancer, the team investigated its role in both lipid metabolism and the progression of invasive bladder cancer.
TERE1 interacts with a cholesterol carrier protein and Dr. Weiss' earlier research found a TERE1 mutation in Schnyder's corneal dystrophy, a rare disease characterized by abnormal deposits of cholesterol and other lipids, or fats, in the cornea leading to progressive loss of vision. An elevated level of cholesterol in cells has also been implicated in the development and progression of breast, colon, liver, head and neck, and melanoma cancers.
The objectives of this study were to confirm that TERE1 levels are reduced in advanced bladder cancer and that TERE1 inhibits the growth of bladder cancer cells. The researchers manipulated the proteins thought to control cell stress, growth signaling, and how cholesterol and other fats are handled in cells and tested them in human bladder cancer cells in a mouse model. They found that TERE1 was reduced in a third of the invasive specimens and that when added to cells, TERE1 dramatically inhibited the development of tumors. They also showed that altering the dosage of TERE1 and another protein implicated in disease associated with triglyceride metabolism, called TBL2, regulates cholesterol in cells and that mutations in TERE1 associated with Schnyder's corneal dystrophy can interfere with binding to a carrier protein that removes cholesterol from cells.
"Research like this helps us target new treatment or prevention approaches for many seemingly unrelated diseases," notes Dr. Jayne Weiss, who also holds the Herbert E. Kaufman, MD Endowed Chair in Ophthalmology at LSU Health Sciences Center New Orleans and is Director of the LSU Eye Center. "Discovering a new component of the dynamic cellular cholesterol regulatory network gives us information that can be applied to every disease arising from a defect in it. Besides Schnyder's corneal dystrophy, this includes many types of cancer."
According to the American Cancer Society, bladder cancer is the fourth leading non-skin cancer in American men, with 52,020 of the 69,250 new cases expected to be diagnosed in men this year. Deaths are estimated at 14,990. Among patients with invasive or advanced disease, therapy consists of radical surgery and/or chemotherapy, which can achieve an overall 5-year survival rate of barely 50%. Those patients with advanced disease have a less than 10% sustained complete response from chemotherapy.
The research team included scientists from the University of Pennsylvania School of Medicine, Kirksville Osteopathic Medical School, Veterans Affairs Medical Center Philadelphia, Gloucester County College, National Cancer Institute, National Heart, Lung, and Blood Institute, and Leibniz Institute of Plan Biochemistry. The research was funded by the Veterans Affairs Medical Center Philadelphia, the Innisfree Foundation of Bryn Mawr, and the Castleman Family Fund.
LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC comprises a School of Medicine, the state's only School of Dentistry, Louisiana's only public School of Public Health, and Schools of Allied Health Professions, Nursing, and Graduate Studies. LSUHSC faculty take care of patients in public and private hospitals and clinics throughout the region. In the vanguard of biosciences research in a number of areas in a worldwide arena, the LSUHSC research enterprise generates jobs and enormous economic impact, LSUHSC faculty have made lifesaving discoveries and continue to work to prevent, advance treatment, or cure disease. To learn more, visit http://www.lsuhsc.edu and http://www.twitter.com/LSUHSCHealth.
Leslie Capo | EurekAlert!
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Earth Sciences
19.07.2018 | Power and Electrical Engineering
19.07.2018 | Materials Sciences