It was previously thought that microglia originated at the same time as macrophages, which are other immune cells that are thought to develop at birth. This groundbreaking discovery has the potential to lead to future treatments of degenerative brain diseases such as Alzheimer's and autoimmune diseases such as multiple sclerosis. The study is published online October 21 in Science Express.
Microglia are thought to play an important role in the development of many brain diseases, and that defective microglia could lead to the release of inflammatory molecules, which could participate in the development of degenerative brain diseases.
"This really is a startling discovery," said Miriam Merad, MD, PhD, Associate Professor of Gene and Cell Medicine at Mount Sinai School of Medicine and Principal Investigator of the study. "We've shown that the precursor cells develop into microglia only during a short period after conception. Now that we know that microglia originate in early embryos, theoretically we should be able to generate microglia from embryonic stem cells to treat brain diseases caused by defective microglia. This is a very good example of why scientists need to be able to conduct research with embryonic stem cells."
For the first part of the study, researchers transplanted blood cell precursors, which are precursors for all macrophages, from one newborn mouse to another. The transplanted cells could not be differentiated in the recipient animal. These results suggest that microglia originated prior to birth during embryonic life.
Next, researchers used a mouse model that expresses fluorescent biosensors in blood precursors to determine when, during embryonic age, precursors develop into microglia. Once activated the fluorescence does not go away and all cells that develop from the fluorescent precursors should remain fluorescent. The researchers activated the fluorescence as early as seven days after conception. When they examined adult mice they found fluorescent microglia but no fluorescent macrophages. These results established that microglia are unique in that they originate from precursors that arise around seven days after conception.
"Moving forward we need to further study the normal development of precursor blood cells into microglia, which should help identify the role of microglia in various brain diseases and ultimately lead to advances in treatments," said Dr. Merad.
About The Mount Sinai Medical Center
The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of few medical schools embedded in a hospital in the United States. It has more than 3,400 faculty in 32 departments and 15 institutes, and ranks among the top 20 medical schools both in National Institute of Health funding and by U.S. News & World Report. The school received the 2009 Spencer Foreman Award for Outstanding Community Service from the Association of American Medical Colleges.
The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. U.S. News & World Report consistently ranks The Mount Sinai Hospital among the nation's best hospitals based on reputation, patient safety, and other patient-care factors. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 530,000 outpatient visits took place.For more information, visit www.mountsinai.org.
Mount Sinai Press Office | EurekAlert!
Brought to light – chromobodies reveal changes in endogenous protein concentration in living cells
21.09.2018 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen
A one-way street for salt
21.09.2018 | Julius-Maximilians-Universität Würzburg
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...
21.09.2018 | Event News
03.09.2018 | Event News
27.08.2018 | Event News
21.09.2018 | Physics and Astronomy
21.09.2018 | Life Sciences
21.09.2018 | Event News