Male infertility can be caused by mutations in the DNA of mitochondria, the powerhouses of cells. By increasing the total DNA amount in mitochondria, scientists from the Max Planck Institute for Biology of Ageing in Cologne restored testis function and semen quality in infertile mice.
Worldwide approximately nine percent of women and men are involuntarily childless. In 40 to 50 percent of the cases this is due to male infertility.
This infertility can be caused by different reasons, one of them are mutations in the mitochondrial DNA.
Mitochondria are tiny energy factories inside the cell and harbor their own independent genome – the mitochondrial DNA (mtDNA).
Mice suffering from a high number of mutations in the mtDNA are infertile and have fewer and less motile sperm.
Max Planck scientist Min Jiang and her colleagues studied these mice and found a way to overcome the consequences of these mutations.
”We increased the total amount of mtDNA in the mitochondria of the testis. This did not change the proportion of mtDNA with mutations, but it increased the absolute number of non-mutated mtDNA, which restored mitochondrial energy production and semen quality”, explains Jiang.
As a next step the researchers want to screen for pharmaceuticals, which could stimulate total mtDNA amount in the testis.
“We hope to find an efficient future strategy to treat or even cure patients suffering from infertility caused by mtDNA mutations”, says Jiang.
Dr. Maren Berghoff | Max-Planck-Institut für Biologie des Alterns
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences