The main risk factors for type 2 diabetes are obesity and a sedentary lifestyle. The biomedical community has known for many years that substances produced by fatty tissue are responsible for the link between obesity and diabetes.
"Chronic inflammation of the adipose tissue, which is characteristic of obese people, is a crucial stage in the development of insulin resistence and type 2 diabetes", Lluis Fajas, lead author of the study and a researcher at the Institute of Health and Medical Research (Inserm) in France, told SINC.
The results of this new study show that serum levels of a chemokine molecule called CXCL5, produced by certain adipose tissue cells, appear at much high levels in the tissues of obese people than in those of individuals with normal weight. This has helped Lluis Fajas's research team to come to a biomedically relevant conclusion: "The CXCL5 molecule helps cause insulin resistance and type 2 diabetes".
The most important part of this study, published in the journal Cell Metabolism, is the discovery that an experimental treatment aimed at inhibiting the action of CXCL5 can help to protect obese mice from develping type 2 diabetes. "If these studies can be confirmed in humans, this treatment would represent a fundamental improvement in the quality of life of obese individuals", the researcher concludes.
Bad habits cause obesity and diabetes
According to the latest data from the Spanish Diabetes Federation (FED), almost 3.5 million people in Spain have diabetes. This illness is most common in Andalusia and Murcia, regions where the highest percentage of people who are obese and sedentary. The specialists agree on the importance of prevention. Avoiding obesity, doing daily physical exercise and giving up smoking are some of the measures that could help to cut the number of diabetes cases by a half.
The International Diabetes Federation (IDF) says that more than 190 million people worldwide currently have diabetes. This figure will rise to 330 million by 2025, due to population growth, the ageing of the population, and increasing urbanisation and sedentary lifestyles. Obesity is the main avoidable risk factor in developing type 2 diabetes. Worldwide, 1.7 billion people are already at high risk of developing a non-contagious, weight-related illness, such as type 2 diabetes.
Obesity can reduce the life expectancy of people with type 2 diabetes by up to eight years, and 80% of people diagnosed with the illness are overweight at the time they are diagnosed.
At least half of all cases of type 2 diabetes among adults could be avoided if they did not put on weight. Taking action on lifestyle, such as changing diet and taking moderate physical exercise, can reduce the risk of developing type 2 diabetes by up to 60%.
Chavey C., Lazennec G., Lagarrigue S., Clapé C., Iankova I., Teyssier J., Annicotte J. S., Schmidt J., Mataki C., Yamamoto H., Sanches R., Guma A., Stich V., Vitkova M., Jardin-Watelet B., Renard E., Strieter R., Tuthill A., Hotamisligil G. S., Vidal-Puig A., Zorzano A., Langin D. y Fajas L. "CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance". Cell Metabolism; 9(4):339-49, abril de 2009.
SINC | EurekAlert!
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences