Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Minimally-invasive hydrogen therapy of cancer based on in-vivo electrochemistry

10.02.2020

Up to now, cancer is still one of the major diseases that threaten the survival of mankind, and it is difficult to cure clinically. In addition to single or combined surgery, chemotherapy and radiotherapy, which are commonly used clinically, a number of promising therapeutic strategies have been recently put forward including immunotherapy and gene therapy, photothermal therapy (PTT), photodynamic therapy, and so on.

However, these techniques usually rely on chemical and genetic drugs or exotic nanomaterials to actualize treatments, making them quite difficult or debatable for practical clinical applications in near future due to the uncertainties of potential biotoxicity and biohazards, and related genetic and ethical issues; and immunotherapy and gene therapy are complex and expensive.


A, Schematic diagram of green H2-ECT therapy in vivo. B, Schematic EC processes of two acupuncture Fe electrodes system showing anodic Fe dissolution and cathodic H2 production. c-e, The H2-production polarization curves of acupuncture electrodes recorded respectively in simulated body fluid (SBF, pH=6.0) under three different voltages (C), in SBF but with different pH (5.5, 6.0, 6.5, 7.0 and 7.5) at 3 V (D), and in fresh pork (mimicking complex tumor tissue) at two pHs (6.0 and 7.4) (E). F, Dissolved amount of iron from the anode during the EC process. G, The dependence of H2 production of the system on various pHs in SBF recorded at 3 V for 10 min (n=3). H-I, The dependence of the amounts of dissolved iron and produced H2 on voltages varying from 0 to 3 V, each for 10 min duration, at the pH=6.0 and 7.4, respectively (n=3).

Credit: ©Science China Press

Therefore, the popularization of these techniques in clinical practice is restricted. Consequently, developing simple, green, efficient and cheap treatment method is an urgent need to combat cancer.

Hydrogen, owing to its small molecular size and physiological inertness, resistance to oxidation, and good gas diffusivity in-vivo, is considered as a kind of green and endogenous gas.

It performs the eminent physiological/pathological regulation functions, which is widely used for the treatment many diseases, such as, Alzheimer's disease, arthritis, diabetes and especially cancer. As early as 1975, researchers have applied the antioxidation of H2 to treat skin squamous cell carcinoma, but it requires using diving medical equipment to provide high pressure H2 which is restricted for clinic tumor therapy applications, how to produce H2 non-invasively and sufficiently without using nanomaterials and how to realize H2 releasing on demand in vivo are two huge challenges facing for the H2 therapy of cancers.

Acupuncture is a traditional and unique minimally-invasive method to treat diseases in China. It is quite effective to treat systemic diseases, especially for arthritis, cervical spondylopathy, psoatic strain and so on. But applying it to the treatment of major diseases, such as cancers is still a great challenge.

In a new research article published in the Beijing-based National Science Review, scientists at the State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China, and at School of Public Health, Jilin University, Changchun, China present the latest advances a green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry.

Co-authors Guo-Hua Qi, Bo Wang, Xiangfu Song, Haijuan Li and Yong-dong Jin report the hydrogen cancer therapy in vivo with electrochemical. They have summarized the development of hydrogen in the treatment of cancer and the key problems limiting its development of clinical application.

These scientists have developed a simple and precise cancer therapy approach based on selective electrochemical generation of H2 in tumor region, termed in-vivo H2 generation electrochemotherapy (H2-ECT) by innovative combined use of traditional Chinese acupuncture Fe needle (electrode) and in-vivo electrochemistry.

The H2-ECT method enables large-scale tumor therapy by applying gas diffusion effect, avoiding the shortcoming of limited effective area for classic electrochemical reactions. Moreover, due to the puncture positioning and acidic tumor microenvironment (compared to normal tissue), the method provides ideal selectivity and targeting to precisely kill tumors with minimal damage to normal tissue, which is very promising for potential clinic applications.

The effectiveness of the method has been demonstrated by successful and fast treatment of glioma and breast cancers in mice in this study. The cost of cancer therapy is very low and less than 1 $ for each treatment.

Scientifically, a green and conceptually new in-vivo H2 generation electrochemotherapy (H2-ECT) of tumor has been developed. Prof. Yongdong Jin said that in a broader perspective, the H2-ECT provides a reliable method for the treatment of cancer and solves the heavy economic burden of cancer therapy bring to the family by high cost, so that it is easily popularized in poor country.

###

This research was supported by the National Key Research and Development Program of China, the National Natural Science Foundation of China, and the Instrument Developing Project of the Chinese Academy of Sciences.

See the article:

Guohua Qi, Bo Wang, Xiangfu Song, Haijuan Li and Yongdong Jin

A green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry

Natl Sci Rev, doi: 10.1093/nsr/nwz199

https://doi.org/10.1093/nsr/nwz199

The National Science Review is the first comprehensive scholarly journal released in English in China that is aimed at linking the country's rapidly advancing community of scientists with the global frontiers of science and technology. The journal also aims to shine a worldwide spotlight on scientific research advances across China.

Media Contact

Yongdong Jin
ydjin@ciac.ac.cn

http://www.scichina.com/ 

Yongdong Jin | EurekAlert!
Further information:
http://dx.doi.org/10.1093/nsr/nwz199

Further reports about: cancer therapy nanomaterials treatment of cancer

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New coronavirus module in SORMAS

HZI-developed app for disease control is expanded to stop the spread of the pathogen

At the end of December 2019, the first cases of pneumonia caused by a novel coronavirus were reported from the Chinese city of Wuhan. Since then, infections...

Im Focus: New insights could lead to superconductivity in ambient conditions

A team of researchers from Switzerland, the US and Poland have found evidence of a uniquely high density of hydrogen atoms in a metal hydride. The smaller spacings between the atoms might enable packing significantly more hydrogen into the material to a point where it could begin to superconduct at room temperature and ambient pressure.

The scientists conducted neutron scattering experiments at the Oak Ridge National Laboratory (ORNL) in the US on samples of zirconium vanadium hydride at...

Im Focus: Viscosity measurements offer new insights into the earth's mantle

An international research group with Dr. Longjian Xie from the Bavarian Research Institute of Experimental Geochemistry & Geophysics (BGI) of the University of Bayreuth has succeeded for the first time in measuring the viscosity that molten solids exhibit under the pressure and temperature conditions found in the lower earth mantle. The data obtained support the assumption that a bridgmanite-enriched rock layer was formed during the early history of the earth at a depth of around 1,000 kilometres – at the border to the upper mantle.

In addition, the data also provides indications that the lower mantle contains larger reservoirs of materials that originated in an early magma ocean and have...

Im Focus: Fast rotating white dwarf drags its space-time in a cosmic dance

According to Einstein's general relativity, the rotation of a massive object produces a dragging of space-time in its vicinity. This effect has been measured, in the case of the Earth’s rotation, with satellite experiments. With the help of a radio pulsar, an international team of scientists (with important contributions from scientists at the Max Planck Institute for Radio Astronomy in Bonn, Germany) were able to detect the swirling of the space-time around its fast-rotating white dwarf-companion star, and thus confirm the theory behind the formation of this unique binary star system.

In 1999, a unique binary system was discovered with the Australian Parkes Radio Telescope in the constellation Musca (the Fly), close to the famous Southern...

Im Focus: Quantum logic spectroscopy unlocks potential of highly charged ions

Scientists from the Physikalisch-Technische Bundesanstalt (PTB) and the Max Planck Institute for Nuclear Physics (MPIK) have carried out pioneering optical measurements of highly charged ions with unprecedented precision. To do this, they isolated a single Ar¹³⁺ ion from an extremely hot plasma and brought it practically to rest inside an ion trap together with a laser-cooled, singly charged ion. Employing quantum logic spectroscopy on the ion pair, they have increased the relative precision by a factor of a hundred million over previous methods. This opens up the multitude of highly charged ions for novel atomic clocks and further avenues in the search for new physics. [Nature, 29.01.2020]

Highly charged ions are—although seemingly exotic—a very natural form of visible matter. All the matter in our sun and in all other stars is highly ionized,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

„Advanced Battery Power“- Conference, Contributions are welcome!

07.01.2020 | Event News

 
Latest News

Scientists discover how rogue communications between cells lead to Leukaemia

10.02.2020 | Life Sciences

Inner “clockwork” sets the time for cell division in bacteria

10.02.2020 | Life Sciences

UNH researchers find synchronization of memory cells critical for learning and forming memories

07.02.2020 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>