Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New marker, new target in Ewing’s sarcoma

02.07.2012
Ewing’s sarcoma is a bone cancer commonly diagnosed in about 250 U.S. teenagers per year. If early chemotherapy is effective, improvement can be durable. But for children and teens who respond poorly to a first attempt at chemotherapy or if the disease spreads, long-term survival can be less than 10 percent.
A University of Colorado Cancer Center study published this week in the journal Molecular Cancer Research shows an important difference that may explain why some respond and some don’t: the existence of high levels of the protein EYA3.

“First, levels of EYA3 could be a tool in offering an accurate prognosis and choosing how aggressively to treat Ewing’s Sarcoma, and second we hope that by lowering levels of EYA3, we could help increase the effectiveness of existing therapies for Ewing’s sarcoma,” says Tyler Robin, PhD, first author of the recent paper.

Researchers recently defined the role of EYA3 as a DNA repair molecule and Tyler showed that EYA3 has a similar repair role in Ewing’s sarcoma – high levels of EYA3 help the tissue survive during and recover after treatment with chemotherapy. Importantly, when Robin knocked down EYA3 in Ewing’s sarcoma cells, they became sensitized to chemotherapy.

“The genetic mutation that creates Ewing’s sarcoma also leads to high levels of EYA3,” says Heide Ford, PhD, investigator at the CU Cancer Center and associate professor in the CU School of Medicine department of ob/gyn, and the paper’s senior author.

The mutation Ford refers to and that creates Ewing’s sarcoma is the fusion of a gene from chromosome 22 to a gene in chromosome 11. Known as a EWS/FLI translocation, this mutation turns off a cell’s ability to make another, intermediate step known as miR-708 – a molecule that helps to decide what parts of the genome do and don’t get read and manufactured into proteins. In healthy tissue, miR-708 turns off the production of EYA3; in Ewing’s sarcoma, miR-708 is down and so EYA3 is up.

“Our next step is to test small molecule inhibitors against EYA3 to determine which inhibitors best sensitize Ewing’s sarcomas to chemotherapy,” says Ford.

Robin and Ford hope that recognizing EYA3 levels, reducing these levels directly, or intervening in the steps that lead to its over-production will help predict outcomes, make decisions about existing treatments, and eventually lead to new treatments for Ewing’s sarcoma.
Funding provided by National Cancer Institute ROICA095277 and F30-CA165873. This work was also supported by The Cancer League of Colorado (PN090325) from grants from the Department of Defense Breast Cancer Research Program

University of Colorado Cancer Center researchers hope that study identifying high levels of the protein EYA3 in Ewing’s sarcoma will lead to more accurate prognosis and eventually improved treatments for the disease, as seen in this MRI of a patient’s left hip. Image: cc license

(W81XWH-10-1-0296) and from the Alex’s Lemonade Stand Foundation for Childhood Cancer and the Boettcher Foundation’s Webb-Waring Biomedical Research Program

Garth Sundem | EurekAlert!
Further information:
http://www.ucdenver.edu

More articles from Life Sciences:

nachricht A new view of microscopic interactions
02.07.2020 | University of Missouri-Columbia

nachricht B-cell protectors
02.07.2020 | Max Delbrück Center for Molecular Medicine in the Helmholtz Association

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The lightest electromagnetic shielding material in the world

Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.

Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...

Im Focus: Gentle wall contact – the right scenario for a fusion power plant

Quasi-continuous power exhaust developed as a wall-friendly method on ASDEX Upgrade

A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...

Im Focus: ILA Goes Digital – Automation & Production Technology for Adaptable Aircraft Production

Live event – July 1, 2020 - 11:00 to 11:45 (CET)
"Automation in Aerospace Industry @ Fraunhofer IFAM"

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM l Stade is presenting its forward-looking R&D portfolio for the first time at...

Im Focus: AI monitoring of laser welding processes - X-ray vision and eavesdropping ensure quality

With an X-ray experiment at the European Synchrotron ESRF in Grenoble (France), Empa researchers were able to demonstrate how well their real-time acoustic monitoring of laser weld seams works. With almost 90 percent reliability, they detected the formation of unwanted pores that impair the quality of weld seams. Thanks to a special evaluation method based on artificial intelligence (AI), the detection process is completed in just 70 milliseconds.

Laser welding is a process suitable for joining metals and thermoplastics. It has become particularly well established in highly automated production, for...

Im Focus: A structural light switch for magnetism

A research team from the Max Planck Institute for the Structure of Dynamics (MPSD) and the University of Oxford has managed to drive a prototypical antiferromagnet into a new magnetic state using terahertz frequency light. Their groundbreaking method produced an effect orders of magnitude larger than previously achieved, and on ultrafast time scales. The team’s work has just been published in Nature Physics.

Magnetic materials have been a mainstay in computing technology due to their ability to permanently store information in their magnetic state. Current...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International conference QuApps shows status quo of quantum technology

02.07.2020 | Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

 
Latest News

The lightest electromagnetic shielding material in the world

02.07.2020 | Materials Sciences

Spintronics: Faster data processing through ultrashort electric pulses

02.07.2020 | Information Technology

International conference QuApps shows status quo of quantum technology

02.07.2020 | Event News

VideoLinks
Science & Research
Overview of more VideoLinks >>>