New cyclotron produces radioactive isotopes for nuclear chemistry to be applied in basic research and the development of clinical applications
A new particle accelerator will further enhance the research landscape at Johannes Gutenberg University Mainz (JGU). It is to be employed to conduct research into potential applications of medical relevance. The new cyclotron has been installed in a basement structure of the Institute of Nuclear Chemistry on the Gutenberg Campus.
It will be used to generate short half-life isotopes, which will be principally used for fundamental research but are also required for the medical imaging technique known as positron emission tomography (PET). The cost of this large-scale research device amounts to about EUR 1 million provided by the German Research Foundation (DFG) and the Rhineland-Palatinate Research Initiative. Commissioning of the new cyclotron is planned for spring 2016.
The cyclotron is a ring-shaped particle accelerator that occupies a floor space of some 7.5 square meters and has a height of two meters. It weighs about 50 tons and a crane had to be used to lower it through a hole in the ceiling into the designated basement room. In addition to the cyclotron room, the new structure has a technical and control center together with an access lock. The structure is linked directly to the Institute of Nuclear Chemistry extension building and has all safety-relevant features.
As it will be able to accelerate protons to an energy of 9.7 mega-electron volts (MeV), the cyclotron at Mainz University can be used to generate the two radioactive elements fluorine-18 and carbon-11. These will be mainly employed for chemical and pharmaceutical research purposes but are also necessary for the PET medical diagnostic imaging technique.
F-18 and C-11 have short half-lives of just 110 and 20 minutes respectively. It is thus necessary to generate them near the location at which they are to be used to ensure that they are available in sufficient quantities. It has not previously been possible in Mainz to create radiopharmaceuticals labeled with C-11 because of its particularly short half-life. The new accelerator has now made this feasible.
"The cyclotron will enhance our currently existing infrastructure and eliminate a bottleneck in the production of radioactive nuclides," explained Professor Frank Rösch of the JGU Institute of Nuclear Chemistry. "It will significantly facilitate the development of new radiopharmaceuticals and their preclinical evaluation while – working in collaboration with the Department of Nuclear Medicine at the Mainz University Medical Center – we will be able to markedly expedite their future application in patient diagnosis."
There are additional benefits to be expected through interdisciplinary joint projects in which the areas of nuclear chemistry, pharmaceutical sciences, organic chemistry, and nuclear medicine at JGU will collaborate with regard to the development and evaluation of new PET radiopharmaceuticals, in some cases also with external institutions such as the Department of Psychiatry, Psychotherapy, and Psychosomatics at RWTH Aachen and the Mainz-based Max Planck Institute for Polymer Research.
Installation of the cyclotron on the campus of Johannes Gutenberg University Mainz
photo/©: Heinz-Martin Schmidt
Installment of a cyclotron door into the newly constructed cyclotron building
photo/©: Heinz-Martin Schmidt
(fltr) Professor Tobias Reich (Managing Director of the Institute of Nuclear Chemistry), Professor Norbert Trautmann (Institute of Nuclear Chemistry), Dr. Waltraud Kreutz-Gers (Chancellor of Johannes Gutenberg University Mainz), Professor Georg Krausch (President of Johannes Gutenberg University Mainz), and Professor Frank Rösch (Institute of Nuclear Chemistry) observing the installation of the new cyclotron
Professor Dr. Frank Rösch
Institute of Nuclear Chemistry
Johannes Gutenberg University Mainz (JGU)
55099 Mainz, GERMANY
phone +49 6131 39-25302
fax +49 6131 39-24692
http://www.kernchemie.uni-mainz.de – Institute of Nuclear Chemistry
http://www.uni-mainz.de/presse/19663_ENG_HTML.php – press release "German Research Foundation, Rhineland-Palatinate, and Mainz University invest more than
EUR 2 million in a cyclotron and its building complex" (19 October 2015)
http://www.uni-mainz.de/presse/20010_ENG_HTML.php - press release ;
http://www.kernchemie.uni-mainz.de/eng/index.php - Institute of Nuclear Chemistry ;
http://www.uni-mainz.de/presse/19663_ENG_HTML.php - press release "German Research Foundation, Rhineland-Palatinate, and Mainz University invest more than EUR 2 million in a cyclotron and its building complex" (19 Oct. 2015)
Petra Giegerich | idw - Informationsdienst Wissenschaft
Colorectal cancer risk factors decrypted
13.07.2018 | Max-Planck-Institut für Stoffwechselforschung
Algae Have Land Genes
13.07.2018 | Julius-Maximilians-Universität Würzburg
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
13.07.2018 | Event News
13.07.2018 | Materials Sciences
13.07.2018 | Life Sciences