Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Key function of protein discovered for obtaining blood stem cells as source for transplants

26.07.2012
With an eye to the future, the results will let cells be obtained in the laboratory that can be transplanted into leukaemia patients with no compatible donors.

Researchers from IMIM (Hospital del Mar Medical Research Institute) have deciphered the function executed by a protein called ¦Â-catenin in generating blood tissue stem cells.


Detail of the aorta of a 10.5 days mouse embryo where we can see in green the cells with activated b-catenin. Some of these cells will be in the future hematopoietic stem cells.

These cells, also called haematopoietic, are used as a source for transplants that form part of the therapies to fight different types of leukaemia. The results obtained will open the doors to produce these stem cells in the laboratory and, thus, improve the quality and quantity of these surgical procedures. This will let patients with no compatible donors be able to benefit from this discovery in the future.

The study, executed jointly with the Erasmus Medical Center Stem Cell of Rotterdam and published in the Journal of Experimental Medicine, analysed a chain of molecular reactions that are produced inside some embryonic cells and that play a role in the creation of a haematopoietic stem cells. ¡®Our study contributes to deciphering the code that makes a precursor cell that is only found in the embryo become a haematopoietic stem cell. In order for that to happen, the ¦Â-catenin protein must be activated for a while and with a specific dosage¡¯ explains Dr Anna Bigas, head of the IMIM Stem Cells & Cancer Group and lead researcher.

This protein also plays a fundamental role in the cells that originate and maintain some types of leukaemia. ¡®The parallelisms between normal and leukaemia stem cells prove to us that the molecular pathways that regulate both populations are the same. For this reason, our work will help us understand the origin of these diseases¡¯, argues Dr Bigas.

In addition to embryonic stem cells, each of our body¡¯s organs has another type of stem cell that has the capacity to regenerate all the cells for the tissue in question. However, they are only formed in the embryonic stage and are maintained for the rest of our lives. Haematopoietic stem cells are part of the blood and, when they are transplanted, they are the inception for all of this tissue¡¯s cells.

At present, transplanting these cells is dependent on the availability of compatible donors. Nonetheless, there is still a high percentage of patients with no donors and that, therefore, cannot be submitted to this procedure. The results of this article lay the foundations so that, in the future, these patients can benefit from a source of laboratory-generated haematopoietic stem cells created from compatible embryonic cells or other types of expressly transformed cells.

Article of reference:

¡°Hematopoietic stem cell development requires transient Wnt/ ¦Â-catenin activity¡± Cristina Ruiz-Herguido, Jordi Guiu, Teresa D¡¯Altri , Julia Ingl¨¦s-Esteve, Elaine Dzierzak, Lluis Espinosa and Anna Bigas Journal of Experimental Medicine 10.1084/jem.20120225

Marta Calsina | EurekAlert!
Further information:
http://www.imim.es

More articles from Life Sciences:

nachricht New way to look at cell membranes could change the way we study disease
19.11.2018 | University of Oxford

nachricht Controlling organ growth with light
19.11.2018 | European Molecular Biology Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

New materials: Growing polymer pelts

19.11.2018 | Materials Sciences

Earthquake researchers finalists for supercomputing prize

19.11.2018 | Information Technology

Controlling organ growth with light

19.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>