Researchers from IMIM (Hospital del Mar Medical Research Institute) have deciphered the function executed by a protein called ¦Â-catenin in generating blood tissue stem cells.
Detail of the aorta of a 10.5 days mouse embryo where we can see in green the cells with activated b-catenin. Some of these cells will be in the future hematopoietic stem cells.
These cells, also called haematopoietic, are used as a source for transplants that form part of the therapies to fight different types of leukaemia. The results obtained will open the doors to produce these stem cells in the laboratory and, thus, improve the quality and quantity of these surgical procedures. This will let patients with no compatible donors be able to benefit from this discovery in the future.
The study, executed jointly with the Erasmus Medical Center Stem Cell of Rotterdam and published in the Journal of Experimental Medicine, analysed a chain of molecular reactions that are produced inside some embryonic cells and that play a role in the creation of a haematopoietic stem cells. ¡®Our study contributes to deciphering the code that makes a precursor cell that is only found in the embryo become a haematopoietic stem cell. In order for that to happen, the ¦Â-catenin protein must be activated for a while and with a specific dosage¡¯ explains Dr Anna Bigas, head of the IMIM Stem Cells & Cancer Group and lead researcher.
This protein also plays a fundamental role in the cells that originate and maintain some types of leukaemia. ¡®The parallelisms between normal and leukaemia stem cells prove to us that the molecular pathways that regulate both populations are the same. For this reason, our work will help us understand the origin of these diseases¡¯, argues Dr Bigas.
In addition to embryonic stem cells, each of our body¡¯s organs has another type of stem cell that has the capacity to regenerate all the cells for the tissue in question. However, they are only formed in the embryonic stage and are maintained for the rest of our lives. Haematopoietic stem cells are part of the blood and, when they are transplanted, they are the inception for all of this tissue¡¯s cells.
At present, transplanting these cells is dependent on the availability of compatible donors. Nonetheless, there is still a high percentage of patients with no donors and that, therefore, cannot be submitted to this procedure. The results of this article lay the foundations so that, in the future, these patients can benefit from a source of laboratory-generated haematopoietic stem cells created from compatible embryonic cells or other types of expressly transformed cells.
Article of reference:
¡°Hematopoietic stem cell development requires transient Wnt/ ¦Â-catenin activity¡± Cristina Ruiz-Herguido, Jordi Guiu, Teresa D¡¯Altri , Julia Ingl¨¦s-Esteve, Elaine Dzierzak, Lluis Espinosa and Anna Bigas Journal of Experimental Medicine 10.1084/jem.20120225
Marta Calsina | EurekAlert!
Why developing nerve cells can take a wrong turn
04.06.2020 | Universität zu Köln
Innocent and highly oxidizing
04.06.2020 | Albert-Ludwigs-Universität Freiburg im Breisgau
In meningococci, the RNA-binding protein ProQ plays a major role. Together with RNA molecules, it regulates processes that are important for pathogenic properties of the bacteria.
Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding...
An analysis of more than 200,000 spiral galaxies has revealed unexpected links between spin directions of galaxies, and the structure formed by these links...
Two prominent X-ray emission lines of highly charged iron have puzzled astrophysicists for decades: their measured and calculated brightness ratios always disagree. This hinders good determinations of plasma temperatures and densities. New, careful high-precision measurements, together with top-level calculations now exclude all hitherto proposed explanations for this discrepancy, and thus deepen the problem.
Hot astrophysical plasmas fill the intergalactic space, and brightly shine in stellar coronae, active galactic nuclei, and supernova remnants. They contain...
In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".
Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...
Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.
researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...
19.05.2020 | Event News
07.04.2020 | Event News
06.04.2020 | Event News
04.06.2020 | Life Sciences
04.06.2020 | Physics and Astronomy
04.06.2020 | Life Sciences