Lyric Bartholomay, assistant professor of entomology, along with colleagues from around the world, infected the common southern house mosquito (Culex quinquefasciatus) with various pathogens to see which mosquito genes are activated in response to the infection.
Bartholomay is the first author on the paper, "Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens," to be published in the Oct. 1 issue of the journal Science.
The southern house mosquito is the third of the three most important mosquito disease carriers to have its genome sequenced. The first was an African mosquito (Anopheles gambiae) that transmits malaria parasites. Malaria infects 250 to 500 million people each year and kills nearly one million people annually, mostly young children in sub-Saharan Africa. The second was a tropical mosquito (Aedes aegypti) that carries yellow and dengue fever viruses.
Bartholomay participated in cataloging the infection-response genes for Aedes aegypti in a manuscript published in 2007. She was chosen to be first author of the current Science paper because she has experience describing the immune responses in the northern house mosquito (Culex pipiens).
In the research, mosquitoes were infected with viruses, worms and bacteria. The genes of the mosquitoes were monitored to see which changed during the response to infection and therefore could ward off disease.
"What we're trying to do is broaden our understanding of infection response genes beyond those that we expect to be there," said Bartholomay.
"We took a two-pronged approach to understanding infection responses," she added. "First, we scoured the genome sequence looking for those immunity genes that the mosquitoes can use to respond to an infection. Then, we looked at what genes comprise broad spectrum and specific immune responses.
"We then took it one step further and compared the infection responses in Culex quinquefasciatus to similar infections in Aedes aegypti and Anopheles gambiae."
Bartholomay noted that the functions of many of the genes revealed in this analysis are still unknown, but as more is discovered about the functions of the genes, it could provide the first steps to controlling mosquito-borne diseases.
Bartholomay also worked with colleagues to analyze the mosquito's genome, as reported in a companion paper that will also be published in the current issue of Science.
Lyric Bartholomay | EurekAlert!
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences