Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Insights into the Development of Epithelial Cells

06.08.2008
Epithelial cells cover all internal and external surfaces of the body. They have an upper and a lower side, which have different functions.

Until now, scientists assumed that these two poles develop in all epithelial cells in the same manner - irrespective of whether they are located in the heart, in the retina, or in the nervous system. Now, Dr. Nana Bit-Avragim, Dr. Nicole Hellwig, and Dr. Salim Abdelilah-Seyfried have shown that, depending on the tissue, a different variation of a complex consisting of five core proteins is active and orientates the epithelial cells. The results of the MDC scientists have now been published in the Journal of Cell Science (2008, Vol. 121, pp. 2503-2510)*.

Scientists worldwide use zebrafish to study the development of vertebrates, the group to which humans also belong. Zebrafish are only a few centimeters long and their embryos are transparent, which is why researchers can observe every change under the microscope. In the early development of zebrafish, the heart is like a tube surrounded by a pump of epithelial cells.

The upper and lower sides of an epithelial cell are clearly different. The upper side, which forms a boundary between organs and either tissue fluid, hollow spaces, or the environment, has a different function than the lower side facing the connective tissue. Both poles of an epithelial cell are vital for the functioning of the heart and other organs.

... more about:
»Development »Heart »epithelial
Different proteins steer cell polarity
Until now, the scientists had assumed that the development of the cell poles was steered by a protein complex which scientists call Crumbs/Nagie oko complex. "What is surprising is that, depending on the tissue, the protein complex has a different composition while being fully functional," Dr. Abdelilah-Seyfried explained. Thus, some proteins in the heart are not needed, but for the development of epithelial cells of the retina they are fundamental. "The program as understood previously may apply for individual cells in the laboratory," Dr. Abdelilah-Seyfried said, "but in a complex organism like the zebrafish, there are many deviations." In the opinion of the researchers, these deviations indicate that the epithelial cells have adapted to their tasks in the respective tissue. Until now, these processes have not been fully elucidated. Next, the MDC researchers want to find out whether still more proteins are involved in epithelial cell polarization.

*Divergent polarization mechanisms during vertebrate epithelial development mediated by the Crumbs complex protein Nagie oko

Nana Bit-Avragim1,2,*, Nicole Hellwig1,*, Franziska Rudolph1, Chantilly Munson3, Didier Y.S. Stainier3 and Salim Abdelilah-Seyfried1,?

1Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany
2Department of Cardiology, The Charité University Medical School of Berlin, Campus Buch, Campus Virchow Clinics, Berlin, Germany

3Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94143-2711, USA

Barbara Bachtler
Press and Public Affairs
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Robert-Rössle-Str. 10¸13125 Berlin, Germany
Phone: +49 (0) 30 94 06 - 38 96; Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de

Barbara Bachtler | idw
Further information:
http://www.mdc-berlin.de/
http://www.mdc-berlin.de/en/research/research_teams/cell_polarity_and_epithelial_development/index.html

Further reports about: Development Heart epithelial

More articles from Life Sciences:

nachricht Cell Division at High Speed
19.06.2019 | Julius-Maximilians-Universität Würzburg

nachricht Monitoring biodiversity with sound: how machines can enrich our knowledge
18.06.2019 | Georg-August-Universität Göttingen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Successfully Tested in Praxis: Bidirectional Sensor Technology Optimizes Laser Material Deposition

The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.

Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

A new force for optical tweezers awakens

19.06.2019 | Physics and Astronomy

New AI system manages road infrastructure via Google Street View

19.06.2019 | Information Technology

A new manufacturing process for aluminum alloys

19.06.2019 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>