To understand how different materials are taken up and what happens within the cells can for example facilitate the development of new vaccines.
"The immune system is a large and important part of ourselves and the dendritic cells are important for the activation of this system", Linda Andersson says.
"One task of the immune system is to protect the body from infections. The dendritic cells have an unique ability to obtain samples from its environment and treat the material, in process called endocytosis. In my study I have explored how dendritic cells recognise and capture particles. "
To study the endocytosing ability of dendritic cells Linda Andersson has used zeolite particles and through them different biomolecules are transported into the cell. With the help of zeolites you can follow different paths and study what happens within the cell.
"The result shows that zeolites are an useful tool for studying endocytosis and that there are differences between various dendritic cells," Linda Andersson says.
A method is developed for studying the early activities of the endocytosing mechanism within the cells. From this you can go further and study other processes and other types of cells.
Zeolites belong to a group of silica particles which easily can adsorb different types of molecules, for example antibodies and other proteins. The type of molecule and the charge and amount of molecules affects the endocytosing ability of the cells.
Dendritic cells are found in different parts of the body, for example skin, mucous, spleen and circulating in the blood. Linda Andersson has chosen to study the cells in the blood. In her study dendritic cells from the blood are compared with dendritic cells produced in vitro, that is from a culture in an artificial environment. Dendritic cells are not so common in the blood. Through in vitro-culture you can easily produce many dendritic cells.
"The differences in the early events of the endocytosing mechanism between these two types of cells were considerable", Linda Andersson says.
This is important to point out, since in vitro-cells are among other things considered in the development of new vaccines. The blood cells are better at taking up particles while the in vitro-cells are better at taking up proteins and soluble molecules.
The thesis by Linda Andersson contributes to an increased understanding of how the important dendritic cells work.
"I hope that the method developed in my study can be used to produce more knowledge about the different paths of the endocytosed material and how the dendritic cells recognise and capture the bodies own material and foreign harmful material", Linda Andersson says.
For more information contact Linda Andersson, tel +46 40 665 79 57, +46 704 94 33 31, e-mail: email@example.com
Pressofficer Hanna Holm; +46-40 665 70 22; Hanna.Holm@mah.se
Hanna Holm | idw
Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland
Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
14.12.2018 | Power and Electrical Engineering
14.12.2018 | Physics and Astronomy
14.12.2018 | Physics and Astronomy