A new Research Training Group aims to decode the complex structure of peptides. The German Research Foundation is to provide EUR 4.5 million in funding for the research
TU Berlin is to act as host university of the new “Bioactive Peptides – Innovative Aspects of Synthesis and Biosynthesis” Research Training Group (RTG2473/1).
The German Research Foundation (DFG) approved the funding of this new Research Training Group on 9 November 2018. Spokesperson will be Professor Roderich Süssmuth. The Research Training Group will conduct research in the areas of molecular biology, biochemistry, biological chemistry and bioanalytics.
Professor Süssmuth has been Rudolf Wiechert Professor of Biological Chemistry at TU Berlin since 2004, where he also heads the Chair of Biological Chemistry. The German Research Foundation will provide the Research Training Group with funding of approximately EUR 4.5 million over a period of four and a half years from 1 April 2019 until 30 September 2023. The German Research Foundation has approved a total of 15 new Research Training Groups.
In biological chemistry, biochemistry and medicinal research, natural and synthetic peptides play a significant role in the development of tools, as products of novel biosynthetic pathways and as binding partners for molecular target structures in drug search.
The various functions of peptides are in large determined by their partially complex molecular structure and their spatial folding. Research on these characteristics will form an essential part of the Research Training Group’s work.
The investigation of mechanisms of biosynthesis and their modes of actions with biological target structures represent further challenges of modern peptide research. These complex issues form the central focus of the new “Bioactive Peptides” Research Training Group.
Peptides are mostly chain-like molecules made up of between two and 100 amino acids - the building blocks of every protein in a cell. Chains made up of more than 100 amino acids are classified as proteins. As such, peptides, which are enormously diverse, can be seen as the “little brothers and sisters” of proteins. In living organisms, they not only function as biocatalysts, semiochemicals and transport substances, but also as storage materials.
Doctoral students participating in the Research Training Group will focus on peptide research via a didactically structured curriculum based on a thorough and interdisciplinary approach. The curriculum’s areas of focus are molecular biology/biochemistry, synthetic chemistry, and bioanalytics/ structural biology.
“In recent years peptide research has achieved a particular importance in academic and industrial research. Consequently, there is a growing need for knowledgeable researchers with excellent academic backgrounds who understand and can speak the language of other disciplines,” Professor Süssmuth explains.
In addition to TU Berlin, the participating institutions in the Research Training Group are Freie Universität Berlin, Humboldt Universität zu Berlin and the Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin-Buch. The teaching staff will be supplemented by contributions from internationally renowned peptide researchers from academia and industry.
High-profile senior scientists will act as advisers within the Research Training Group. Professor Süssmuth sees the undertaking overall as a sustainable project which all participating research groups look forward to being involved in.
For further information please contact:
Prof. Dr. Roderich Süssmuth
Chair of Biological Chemistry
Stefanie Terp | idw - Informationsdienst Wissenschaft
Platinum nanoparticles for selective treatment of liver cancer cells
15.02.2019 | ETH Zurich
New molecular blueprint advances our understanding of photosynthesis
15.02.2019 | DOE/Lawrence Berkeley National Laboratory
For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy and computer simulations, they were able to show that DNA molecules behave like a chain of small coil springs. The researchers reported their findings in Nature Communications.
DNA is not only a popular research topic because it contains the blueprint for life – it can also be used to produce tiny components for technical applications.
11.02.2019 | Event News
30.01.2019 | Event News
16.01.2019 | Event News
15.02.2019 | Physics and Astronomy
15.02.2019 | Physics and Astronomy
15.02.2019 | Life Sciences