Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Identified an anti-oncogene into an oncogene

06.06.2012
A study led by Manel Esteller has discovered the existence of an antitumor molecule that has been originated within an oncogene.

A common point in all human tumors is that they produce an activation of oncogenes, genes that cause cancer and they also cause a loss of function of the protective genes, called anti-oncogenes or tumor suppressor genes. Normally both categories of anticancer and procancer genes are in different regions of our chromosomes.


Example of three colon tumors (up) whose growth was inhibited (down) a molecule of RNA (ribonucleic acid) which acts as identified anti-oncogene.

A study coordinated by Manel Esteller, Director of the program of epigenetics and cancer biology at the Bellvitge Institute for Biomedical Research (IDIBELL), Professor of genetics at the University of Barcelona and ICREA researcher, has discovered the existence of an antitumor molecule that originates within an oncogene. The finding is published this week in the Nature Structural & Molecular Biology journal.

The identified anti-oncogene is along non-coding ribonucleic acid (lncRNA), ie a molecule that does not produce protein itself but is responsible for regulating the expression of other proteins. Specifically, the identified molecule is produced in a cancer-causing gene (SMYD3) as its role in healthy cells is to inhibit pro-cancer action of the oncogene.

If you enter this fragment of ribonucleic acid on cancer cells growing in laboratory or in human tumors implanted in animals for research is able to block cancer growth. "We believe this discovery will be the starting point to find many other oncogenes and anti-oncogenes that coexist in regions of our genome, that when their life together deteriorates, contribute to the development of human tumors," said Dr. Esteller.

Paper:

Intronic RNAs mediate EZH2 regulation of epigenetic targets. Sònia Guil*, Marta Soler*, Anna Portela*, Jordi Carrère*, Elena Fonalleras*, Antonio Gómez*, Alberto Villanueva* and Manel Esteller*. Nature Structural & Molecular Biology (NSMB), Early Edition, May 21, 2012.

* IDIBELL Researchers

Raül Toran | EurekAlert!
Further information:
http://www.idibell.cat

More articles from Life Sciences:

nachricht Cancer cachexia: Extracellular ligand helps to prevent muscle loss
25.02.2020 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

nachricht The genetic secret of night vision
25.02.2020 | Max-Planck-Institut für molekulare Zellbiologie und Genetik

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: High-pressure scientists in Bayreuth discover promising material for information technology

Researchers at the University of Bayreuth have discovered an unusual material: When cooled down to two degrees Celsius, its crystal structure and electronic properties change abruptly and significantly. In this new state, the distances between iron atoms can be tailored with the help of light beams. This opens up intriguing possibilities for application in the field of information technology. The scientists have presented their discovery in the journal "Angewandte Chemie - International Edition". The new findings are the result of close cooperation with partnering facilities in Augsburg, Dresden, Hamburg, and Moscow.

The material is an unusual form of iron oxide with the formula Fe₅O₆. The researchers produced it at a pressure of 15 gigapascals in a high-pressure laboratory...

Im Focus: From China to the South Pole: Joining forces to solve the neutrino mass puzzle

Study by Mainz physicists indicates that the next generation of neutrino experiments may well find the answer to one of the most pressing issues in neutrino physics

Among the most exciting challenges in modern physics is the identification of the neutrino mass ordering. Physicists from the Cluster of Excellence PRISMA+ at...

Im Focus: Therapies without drugs

Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master.

A study by the Robert Koch Institute has found that one in four women will suffer from weak bladders at some point in their lives. Treatments of this condition...

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Turbomachine expander offers efficient, safe strategy for heating, cooling

25.02.2020 | Power and Electrical Engineering

The seismicity of Mars

25.02.2020 | Earth Sciences

Cancer cachexia: Extracellular ligand helps to prevent muscle loss

25.02.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>