Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How neural circuits drive hungry individuals to peak performance: The secret of motivation

26.09.2019

Success is no accident: To reach your goal you need perseverance. But where does the motivation come from? An international team of researchers led by scientists from the Technical University of Munich (TUM) has now identified the neural circuit in the brain of fruit flies which makes them perform at their best when searching for food.

The odor of vinegar or fruit lets fruit flies walk faster. To reach the food, they run until exhaustion. But despite their efforts, they do not get any closer to their goal: In the set-up at the laboratory of the TUM School of Life Sciences Weihenstephan the upper bodies of the tiny flies are fixed in place and the flies are running without getting anywhere.


Prof. Ilona C. Grunwald Kadow choses drosophila flies for her motivation experiments.

Image: Astrid Eckert / TUM


Set-up for measuring the motivation of fruit flies.

Image: A. Eckert / TUM

With the movement of their legs they are turning a ball which is floating on an air cushion. The turning speed shows neurobiologist professor Ilona C. Grunwald Kadow how much effort the fruit fly is putting into finding food.

“Our experiments show that hungry individuals keep increasing their performance – they run up to nine meters per minute. Fruit flies which are full give up much faster”, the researcher reports. “This proves that even simple organisms show stamina and perseverance – up to now, these qualities were thought to be reserved for humans and other higher organisms.”

A neural circuit controls perseverance

Together with Julijana Gjorgjieva, Professor for Computational Neuroscience at the Technical University of Munich and group leader at the Max-Planck-Institute for Brain Research in Frankfurt, as well as an international and interdisciplinary team of researchers, Grunwald Kadow has now identified a neural circuit in the brain of the small flies, which controls this kind of perseverance.

It is not a coincidence that the researchers investigated the motivation of fruit flies. “The brains of these flies have a million times fewer nerve cells than human brains. This makes it a lot easier to find out what an individual neuron does and how”, the professor explains. “In this way, we are able to understand the principles of neural circuits which also form the basis for the function of complex brains.”

The power of neurons

To identify the neural circuit which is responsible for motivation, the team used various techniques: First, a mathematical model was created which simulates the interaction of external and internal stimuli – for example the odor of vinegar and hunger.

In the next step, the neuroscientists of TUM identified the network of interest in the brain of the fruit fly in cooperation with colleagues in the USA and Great Britain. This was achieved with the help of electron microscopy as well as in-vivo imaging and behavioral experiments.

The result: The neural circuit of interest is located in the learning and memory center of the fly brain. It is controlled by the two neurotransmitters dopamine and octopamine, which is related to the human noradrenaline. Dopamine increases the activity of the circuit, i. e. increases motivation; octopamine reduces the willingness to make an effort.

“Since these neurotransmitters and the corresponding circuits also exist in the brains of mammals, we assume that similar mechanisms decide whether to continue or to stop”, concludes the neurobiologist. In the long term, the researchers hope that their findings will help to understand why the interaction of neurons and messenger substances in the brain, for example, in addictions gets out of control.

Wissenschaftliche Ansprechpartner:

Prof. Dr. Ilona Grunwald Kadow

Technical University of Munich
TUM School of Life Sciences
ZIEL – Institute for Food and Health

Liesel-Beckmann-Str. 4, 85354 Freising, Germany
Tel.: +49 8161 71 2440 – E-Mail: ilona.grunwald@tum.de

Originalpublikation:

Sercan Sayin, Jean-Francois De Backer, K.P. Siju, Marina E. Wosniack, Laurence P. Lewis, Lisa-Marie Frisch, Benedikt Gansen, Philipp Schlegel, Amelia Edmondson-Stait, Nadiya Sharifi, Corey B. Fisher, Steven A. Calle-Schuler, J. Scott Lauritzen, Davi D. Bock, Marta Costa, Gregory S.X.E. Jefferis, Julijana Gjorgjieva, Ilona C. Grunwald Kadow
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila
Neuron 104, 1–15, November 6, 2019 – DOI: 10.1016/j.neuron.2019.07.028
https://doi.org/10.1016/j.neuron.2019.07.028

Weitere Informationen:

https://www.tum.de/nc/en/about-tum/news/press-releases/details/35707/ Link to the press release

Dr. Ulrich Marsch | Technische Universität München
Further information:
http://www.tum.de

Further reports about: flies fruit fly individuals neural circuit neurons neurotransmitters octopamine

More articles from Life Sciences:

nachricht Biophysicists reveal how optogenetic tool works
29.05.2020 | Moscow Institute of Physics and Technology

nachricht Mapping immune cells in brain tumors
29.05.2020 | University of Zurich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Biotechnology: Triggered by light, a novel way to switch on an enzyme

In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".

Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

Im Focus: I-call - When microimplants communicate with each other / Innovation driver digitization - "Smart Health“

Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.

When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...

Im Focus: When predictions of theoretical chemists become reality

Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.

Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...

Im Focus: Rolling into the deep

Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

Black nitrogen: Bayreuth researchers discover new high-pressure material and solve a puzzle of the periodic table

29.05.2020 | Materials Sciences

Argonne researchers create active material out of microscopic spinning particles

29.05.2020 | Materials Sciences

Smart windows that self-illuminate on rainy days

29.05.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>