Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How cellular structure orchestrates immunologic memory

08.03.2018

With every infection or vaccination, memory cells form that the body uses to remember the pathogen. This has been known for decades – but the structure of this cellular immunologic memory has previously proven impossible to pin down. Researchers from the University of Basel and University Hospital Basel have now identified a microanatomical region in memory cells that enables them to work rapidly in the first few hours of an immune response, as they report in the journal Immunity.

The human body’s immune system remembers disease-causing pathogens and can react more quickly in case of renewed contact. Vaccines are a prime example of how immunologic memory can protect us from infectious diseases.


Example of a connection between a mitochondrium and the endoplasmic reticulum. These connections enable the memory CD8 T-cells to protect us quickly from infections.

In terms of its function and effect, immunologic memory is well understood – an individual remains healthy despite being exposed to the pathogen. However, the specific cellular structures that enable immunologic memory were previously unknown.

An international group of researchers led by Professor Christoph Hess from the Department of Biomedicine at the University of Basel and University Hospital Basel have now found a structure that accounts for the rapid immunologic memory of particular immune cells (CD8+ memory T cells): these important memory cells form multiple connections between mitochondria – the powerhouses of cells – and the endoplasmic reticulum, the site of protein production.

Rapid immune response

At these contact sites, the rapid immune memory response is literally “orchestrated”, say the researchers. The memory cells concentrate all the signal transmission molecules and enzymes necessary for a rapid immune response here – and so are prepared when the organism is once again exposed to the disease-causing pathogen. This allows the body to quickly protect itself against the infection.

Original source

Glenn R. Bantug, Marco Fischer, Jasmin Grählert, Maria L. Balmer, Gunhild Unterstab, Leyla Develioglu, Rebekah Steiner, Lianjun Zhang, Ana S.H. Costa, Patrick M. Gubser, Anne-Valérie Burgener, Ursula Sauder, Jordan Löliger, Réka Belle, Sarah Dimeloe, Jonas Lötscher, Annaïse Jauch, Mike Recher, Gideon Hönger, Michael N. Hall, Pedro Romero, Christian Frezza, and Christoph Hess
Mitochondria–Endoplasmic Reticulum contact sites function as immunometabolic hubs that orchestrate the rapid recall response of memory CD8 T cells
Immunity (2018), doi: 10.1016/j.immuni.2018.02.012

Further Information

Prof. Dr. Christoph Hess, University of Basel, Department of Biomedicine, Immunobiology, phone: +41 61 328 68 30, e-mail: chess@uhbs.ch

Weitere Informationen:

https://www.unibas.ch/en/News-Events/News/Uni-Research/How-cellular-structure-or...

Cornelia Niggli | Universität Basel

More articles from Life Sciences:

nachricht The Secret of the Rock Drawings
24.05.2019 | Max-Planck-Institut für Chemie

nachricht Chemical juggling with three particles
24.05.2019 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New studies increase confidence in NASA's measure of Earth's temperature

A new assessment of NASA's record of global temperatures revealed that the agency's estimate of Earth's long-term temperature rise in recent decades is accurate to within less than a tenth of a degree Fahrenheit, providing confidence that past and future research is correctly capturing rising surface temperatures.

The most complete assessment ever of statistical uncertainty within the GISS Surface Temperature Analysis (GISTEMP) data product shows that the annual values...

Im Focus: The geometry of an electron determined for the first time

Physicists at the University of Basel are able to show for the first time how a single electron looks in an artificial atom. A newly developed method enables them to show the probability of an electron being present in a space. This allows improved control of electron spins, which could serve as the smallest information unit in a future quantum computer. The experiments were published in Physical Review Letters and the related theory in Physical Review B.

The spin of an electron is a promising candidate for use as the smallest information unit (qubit) of a quantum computer. Controlling and switching this spin or...

Im Focus: Self-repairing batteries

UTokyo engineers develop a way to create high-capacity long-life batteries

Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...

Im Focus: Quantum Cloud Computing with Self-Check

With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.

Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...

Im Focus: Accelerating quantum technologies with materials processing at the atomic scale

'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.

However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

On Mars, sands shift to a different drum

24.05.2019 | Physics and Astronomy

Piedmont Atlanta first in Georgia to offer new minimally invasive treatment for emphysema

24.05.2019 | Medical Engineering

Chemical juggling with three particles

24.05.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>