Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Good fat: researchers at the University of Graz prove that lipids are essential for cell renewal

12.08.2019

Lipids play an essential role for cell renewal, as bioscientist Tobias Eisenberg and his team at the University of Graz have just found out. Their findings have been published in the latest issue of the Journal of Biological Chemistry

Recycling is also a vital process in the cells of the human body. Using the process known as autophagy, cells break down defective and therefore potentially damaging proteins and organelles. This helps to counteract ageing, metabolic disorders and other diseases such as cancer.


Die Abbildung zeigt alternde Hefezellen im Lichtmikroskop (links). Durch Fluoreszenzfärbungen (rechts) wurde der „Magen“ der Zellen (die sog. Vakuole) sichtbar gemacht (Magenta färbig). In gesunden Zellen können Proteine, die mittels grüner Fluoreszenz markiert wurden, durch Autophagie recycelt werden (oben rechts). Zellen mit gestörtem Fettstoffwechsel (unten rechts) zeigen einen Autophagiedefekt und scheitern beim Transport der grün-markierten Proteine in die Vakuole und Altern schneller. Bild: Uni Graz/Eisenberg

Tobias Eisenberg and his team at the University of Graz’s Institute of Molecular Biosciences have now been able to prove for the first time, using a yeast model, that certain newly produced lipids – fat molecules – are essential for this cleaning process. Their research findings have been published in the current edition of the Journal of Biological Chemistry.

The researchers experimented with modulating the step that determines the speed at which fatty acids are produced in the cell: the so-called Acetyl-CoA carboxylase (Acc1).

Yeasts in which Acc1 was inhibited, so that they were only able to produce a limited quantity of lipids themselves, showed defective autophagy during ageing and a significantly higher mortality rate.

In contrast, stimulation of Acc1 enhanced the autophagy competence of ageing cells. “This is an important insight for our understanding of this recycling process, and sheds new light on the significance of lipogenesis, i.e. the formation of new lipids,” says Eisenberg, summarising their findings.

The researchers believe that their discovery may also have relevance for metabolic disorders. The precise links will be investigated in further studies in corresponding disease models.

Publication:
Gross, Zimmermann, Pendl et al.: Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK, Journal of Biological Chemistry
DOI: 10.1074/jbc.RA118.007020

Wissenschaftliche Ansprechpartner:

Ass.-Prof. Dr. Tobias Eisenberg
tobias.eisenberg@uni-graz.at
+43 316 380 1499

Originalpublikation:

Publication:
Gross, Zimmermann, Pendl et al.: Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK, Journal of Biological Chemistry
DOI: 10.1074/jbc.RA118.007020

Mag. Dagmar Eklaude | Karl-Franzens-Universität Graz
Further information:
https://news.uni-graz.at/en/detail/article/gutes-fett/

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A miniature stretchable pump for the next generation of soft robots

Soft robots have a distinct advantage over their rigid forebears: they can adapt to complex environments, handle fragile objects and interact safely with humans. Made from silicone, rubber or other stretchable polymers, they are ideal for use in rehabilitation exoskeletons and robotic clothing. Soft bio-inspired robots could one day be deployed to explore remote or dangerous environments.

Most soft robots are actuated by rigid, noisy pumps that push fluids into the machines' moving parts. Because they are connected to these bulky pumps by tubes,...

Im Focus: Vehicle Emissions: New sensor technology to improve air quality in cities

Researchers at TU Graz are working together with European partners on new possibilities of measuring vehicle emissions.

Today, air pollution is one of the biggest challenges facing European cities. As part of the Horizon 2020 research project CARES (City Air Remote Emission...

Im Focus: Self healing robots that "feel pain"

Over the next three years, researchers from the Vrije Universiteit Brussel, University of Cambridge, École Supérieure de Physique et de Chimie Industrielles de la ville de Paris (ESPCI-Paris) and Empa will be working together with the Dutch Polymer manufacturer SupraPolix on the next generation of robots: (soft) robots that ‘feel pain’ and heal themselves. The partners can count on 3 million Euro in support from the European Commission.

Soon robots will not only be found in factories and laboratories, but will be assisting us in our immediate environment. They will help us in the household, to...

Im Focus: Scientists create the world's thinnest gold

Scientists at the University of Leeds have created a new form of gold which is just two atoms thick - the thinnest unsupported gold ever created.

The researchers measured the thickness of the gold to be 0.47 nanometres - that is one million times thinner than a human finger nail. The material is regarded...

Im Focus: Study on attosecond timescale casts new light on electron dynamics in transition metals

An international team of scientists involving the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) in Hamburg has unraveled the light-induced electron-localization dynamics in transition metals at the attosecond timescale. The team investigated for the first time the many-body electron dynamics in transition metals before thermalization sets in. Their work has now appeared in Nature Physics.

The researchers from ETH Zurich (Switzerland), the MPSD (Germany), the Center for Computational Sciences of University of Tsukuba (Japan) and the Center for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

4th Hybrid Materials and Structures 2020 28 - 29 April 2020, Karlsruhe, Germany

14.08.2019 | Event News

What will the digital city of the future look like? City Science Summit on 1st and 2nd October 2019 in Hamburg

12.08.2019 | Event News

Jena Laser Technology Conference brings together top international researchers

12.08.2019 | Event News

 
Latest News

Climate change 'disrupts' local plant diversity, study reveals

16.08.2019 | Life Sciences

Finnish discovery brings new insight on the functioning of the eye and retinal diseases

16.08.2019 | Life Sciences

A Rescue Plan for the Ocean

16.08.2019 | Ecology, The Environment and Conservation

VideoLinks
Science & Research
Overview of more VideoLinks >>>