Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genome of the brown bear is now sequenced - scientists hope to learn about adaptations to climate

12.10.2011
A research group led by Prof. Axel Janke at the Biodiversity and Climate

Research Centre (BiK-F) in Frankfurt am Main has just finished sequencing the genome of the brown bear. The work was done in collaboration the Norwegian research institute Bioforsk and the Chinese genome-sequencing institute BGI.


Male Brown Bear
Copyright: Alexander Kopatz, Bioforsk

The researchers will now compare the brown bear sequence to the recently released genome sequences of polar bear and giant panda. The brown bear genome could ultimately be the key to identify genes that are relevant for environmental adaptation.

He is truly a mighty one – the brown bear is, together with the polar bear, the world's largest living land predator. In one of the first German mammalian genome projects, its genetic make-up, the genome, has now been sequenced. The “pilot bear” as he is nicknamed, was a male brown bear from the Pasvik Valley, Northern Norway and its genome is a spark for new research on this species. One of the partners, the Chinese genome center BGI, had also recently released the genome of the polar bear. Prof. Dr. Axel Janke, BiK-F, head of the research team, says: “With the entire genome sequences of those two bears, we have an incredible resource at hand to understand the genetic basis of adaptation to different climates. The genome sequences will also prove an invaluable resource to study other aspects of bear biology, and will help us to better understand and protect those fascinating animals.”

Brown bear genome: essential reference point to understand climate adaptation in polar bear

The particular significance of the brown bear genome springs from the bear’s close relationship to the polar bear – the flagship species of climate change. Recent studies at BiK-F show that the two bears diverged from each other less than a million years ago and the species are much older than previously thought “Thus, comparing their genomes will tell much about how they managed to adapt to different climates”, as Prof. Dr. Axel Janke (BiK-F) points out: “They are a terrific study system to understand what genetic make-up allows a mammal to survive under arctic or temperate climate conditions. Comparative genomics has already taught us a lot about evolutionary processes in humans, Neanderthals and chimpanzees. Now the bears will be the second mammalian group where the whole genomes of very close relatives can be studied and our“pilot bear” will become immortal.”

The brown bear genome is just the starting point for a series of genome research projects on this species, as Janke further explains: “The entire history of the brown bear is written in its genome and it will take years to completely decipher it. Even in humans, with several complete genomes and several millions of other sequences and medical data being available, the genome research has only just begun. However, comparative genomics is immensely profiting from this field.”

The brown bear genome enables advanced migration studies

The brown bear genome will not only be useful to study climate adaption, but also for conservation aspects. “The data will allow the development of new genetic markers that are urgently needed for conservation and wildlife management”, says Dr. Hans-Geir Eiken from Norwegian Bioforsk. The institute closely monitors Scandinavian and Russian bear populations. While a number of studies have looked at maternally inherited mitochondrial DNA to study the population history and migration patterns of females, no relevant markers from the Y-chromosome are available to study male migration. The genome of the male brown bear will now enable such studies. “Many previous mammalian genomes came from females and were thus missing Y-chromosome sequences”, Dr. Eiken points out. He and his colleagues are eager to start the work, once the initial assembly and genome analyses have been completed.

A complete mammalian genome is also a rich resource for countless follow-up studies by evolutionary biologists and geneticists. For instance, mammalian genomes consist to a large part of non-coding sequences, so-called ”jumping genes” (transposable elements). Transposable elements typically account for one third to half of a mammalian genome and have a yet unknown impact on gene function, evolution and adaptation, because until now most studies looked at single loci of genes rather than whole genomes of species that are closely related.

For studying the vast amount of data and complexity of this and other questions, Janke’s BiK-F research team consists of experts in the fields of bioinformatics, population genetics and the genetics of transposable elements. Together with Bioforsk, among others, the data are currently being analyzed and the first results are expected shortly. Next to Janke and Eiken, the research is conducted by Dr. Björn Hallström, Dr. Frank Hailer, Dr. Maria Nilsson, Verena Kutschera and Vikas Kumar from BiK-F as well as Bioforsk scientists Alexander Kopatz, Dr. Oddmund Kleven and Dr. Snorre Hagen.

For further information please contact:

Prof. Dr. Axel Janke
LOEWE Biodiversity and Climate Research Centre (BiK-F)
Phone +49 69 79824774 or +49 69 7542 1842
email: axel.janke@senckenberg.de
and
Dr. Hans Geir Eiken
Norwegian Institute for Agricultural and Environmental Research - Svanhovd
Phone +47 99629966
email: HansGeir.Eiken@bioforsk.no
and
Dr. Snorre B. Hagen
Norwegian Institute for Agricultural and Environmental Research - Svanhovd
Phone +47 93240197
email: snorre.hagen@bioforsk.no
or
Sabine Wendler
LOEWE Biodiversity and Climate Research Centre (BiK-F), press officer
Phone +49 69 7542 1838
email: sabine.wendler@senckenberg.de
LOEWE Biodiversität und Klima Forschungszentrum, Frankfurt am Main, Germany
With the objective of analysis the complex interactions between biodiversity and climate through a wide range of methods, the Biodiversität und Klima Forschungszentrum [Biodiversity and Climate Research Centre] (BiK-F) has been funded since 2008 within the context of the Landes-Offensive zur Entwicklung Wissenschaftlich ökonomischer Exzellenz (LOEWE) of the Land of Hessen. The Senckenberg Gesellschaft für Naturforschung and Goethe University in Frankfurt as well as other, directly involved partners, co-operate closely with regional, national and international institutions in the fields of science, resource and environmental management, in order to develop projections for the future and scientific recommendations for sustainable action.

Sabine Wendler | idw
Further information:
http://www.bik-f.de
http://www.senckenberg.de

More articles from Life Sciences:

nachricht Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland

nachricht Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>