Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fungal weapon turns against the maker

17.10.2018

An international research team led by Bernhard Hube from the Leibniz Institute for Natural Product Research and Infection Biology in Jena has solved another mystery of the yeast Candida albicans: They discovered that its fungal toxin Candidalysin boycotts its pathogenic effect by attracting immune cells. The scientists published their results in the journal Nature Communications.

Like many microorganisms, Candida albicans lives as a commensal, i.e. harmless beneficiary in the human digestive tract. It is part of a healthy microbiome. However, if the microbiome becomes unbalanced and the number of yeast cells increases, human macrophages intervene to regulate the fungus.


Macrophages (red) and the yeast Candida albicans (blue)

Source: Andrea Hartmann, Leibniz-HKI

They absorb the fungus, which in return grows thread-like and produces the toxin Candidalysin. This toxin attacks the macrophages and destroys them. Thus Candida albicans escapes the grasp of the immune system and continues to multiply until the person eventually falls ill.

But it does not always come to that, as the research team from Germany, Great Britain, the USA and Canada has now discovered: the macrophage recognizes the toxin before it unfolds its deadly effect and triggers inflammation. This attracts other immune cells, especially neutrophils.

These finally eliminate the yeast. Candidalysin thus contributes on the one hand to the virulence of the pathogen by destroying host cells; on the other hand it fights itself by activating the immune defence. As a virulence factor, the toxin thus promotes the disease.

However, under certain circumstances it prevents it and is then an avirulence factor.

"It is possible that the dual function of Candidalysin we found is the result of the joint evolution of pathogen and host: The human immune system has learned to recognise the weapon of the pathogen and then launches the counterattack," says group leader Bernhard Hube, head of department at the Leibniz-HKI and professor at the Friedrich Schiller University Jena. "We will now elucidate which conditions favour the avirulence property of Candidalysin over its toxicity," Hube adds.

Wissenschaftliche Ansprechpartner:

Bernhard Hube
bernhard.hube@leibniz-hki.de

Originalpublikation:

Kasper L, König A, Koenig PA, Gresnigt MS, Westman J, Drummond, RA, Lionakis MS, Groß O, Ruland J, Naglik, JR, Hube B (2018) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nature Communications, DOI: 10.1038/s41467-018-06607-1.

Dr. Michael Ramm | idw - Informationsdienst Wissenschaft
Further information:
http://www.hki-jena.de

More articles from Life Sciences:

nachricht Researchers find new mutation in the leptin gene
24.06.2019 | Texas Biomedical Research Institute

nachricht Straight to the heart
24.06.2019 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fraunhofer IDMT demonstrates its method for acoustic quality inspection at »Sensor+Test 2019« in Nürnberg

From June 25th to 27th 2019, the Fraunhofer Institute for Digital Media Technology IDMT in Ilmenau (Germany) will be presenting a new solution for acoustic quality inspection allowing contact-free, non-destructive testing of manufactured parts and components. The method which has reached Technology Readiness Level 6 already, is currently being successfully tested in practical use together with a number of industrial partners.

Reducing machine downtime, manufacturing defects, and excessive scrap

Im Focus: Successfully Tested in Praxis: Bidirectional Sensor Technology Optimizes Laser Material Deposition

The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.

Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on UV LED Technologies & Applications – ICULTA 2020 | Call for Abstracts

24.06.2019 | Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

 
Latest News

2nd International Conference on UV LED Technologies & Applications – ICULTA 2020 | Call for Abstracts

24.06.2019 | Event News

'Sneezing' plants contribute to disease proliferation

24.06.2019 | Agricultural and Forestry Science

Researchers find new mutation in the leptin gene

24.06.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>