Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fluorescence monitoring and effect of photodynamic therapy for port wine stains

02.03.2010
It is known that fluctuations in the treatment outcome of photodynamic therapy (PDT) between patients are related to the concentration of photosensitizer in target tissue.

The purpose of a study, by Wang et al, published in the February 2010 issue of Experimental Biology and Medicine was to establish a fluorescence method not only providing a semi-quantitative measurement of photosensitizer concentration but also predicting the efficacy of PDT for Port Wine Stains (PWS).

This work was conducted by Ying Wang and Xiaohua Liao when they were postgraduate students under the direction of Professor Ying Gu and Professor Rong Chen, and colleagues in the Department of Laser Medicine at the Chinese People's Liberation Army General Hospital. Currently, Ying Wang is a physician at Chinese PLA General Hospital, Xiaohua Liao works at Fujian Metrology Institute. An algorithm which can yield a semi-quantitative measurement of photosensitizer concentration was established in this study. Then a therapeutic effect correlation index (TECI) was proposed as the area under the photosensitizer concentration-time curve during PDT. The correlation between TECI and PDT treatment outcome was analyzed from 31 PWS patients at the Chinese People's Liberation Army General Hospital.

Dr. Wang noted that "A non-invasive fluorescence method that can monitor photosensitizer concentration during PDT for PWS was established, and a therapeutic effect correlation index (TECI) was verified to be positively correlated with PDT outcome for the first time in this paper."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "The results of the study by Wang et al suggest that fluorescence spectroscopy can be used in situ to monitor skin photosensitizer concentration during PDT. This may provide a valuable diagnostic tool to predict PDT outcome."

Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit www.sebm.org. If you are interested in publishing in the journal please visit www.ebmonline.org

Dr. Ying Gu | EurekAlert!
Further information:
http://www.sebm.org
http://www.ebmonline.org

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>