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Flavins keep a handy helper in their pocket

25.04.2018

In human cells, vitamins often serve as the precursors of "cofactors" - non-proteins which are an essential part of enzymes. Among them are the flavins, which the organism derives from vitamin B2.

A team headed by Dr. Robin Teufel and Dr. Raspudin Saleem-Batcha of the University of Freiburg at the Center for Biological Systems Analysis has now shown in detail how oxygen interacts with the flavin in an enzyme - revealing for the first time precisely how it works.


In the active center of the enzyme is a flavin cofactor. In the enlargement we can see that near it, oxygen (O2) is bound -- enabling the flavin to be activated.

Source: Robin Teufel, Raspudin Saleem-Batcha

The researchers have published their results in the latest Proceedings of the National Academy USA (PNAS).

Flavins play a key role in metabolic processes, in the immune system and in neural development in humans - and are equally important to bacteria, fungi and plants.

Flavoenzymes often require oxygen to function. But until now many of the details of their interaction were not known.

The researchers used x-ray diffraction analysis to show for the first time that oxygen is bound to a special pocket inside the enzyme.

The nature of this compound makes it possible to activate the cofactor - making it essential for the enzyme to work. This knowledge may help, for example, to rationally modify flavoenzymes in the future - in basic research or for biotechnological applications.

###

Original publication:

Raspudin Saleem-Batcha, Frederick Stull, Jacob N. Sanders, Bradley S. Moore, Bruce A. Palfey, K. N. Houk, Robin Teufel: Enzymatic control of dioxygen binding and functionalization of the Flavin cofactor. In: Proceedings of the National Academy of Sciences USA. DOI: 10.1073

http://www.pnas.org/cgi/doi/10.1073/pnas.1801189115

Contact:

Center for Biological Systems Analysis
University of Freiburg

Media Contact

Dr. Robin Teufel
robin.teufel@zbsa.de
49-761-203-97199

http://www.uni-freiburg.de/ 

Dr. Robin Teufel | EurekAlert!

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