Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fish Oil-Diet Benefits May be Mediated by Gut Microbes

28.08.2015

Diets rich in fish oil versus diets rich in lard produce very different bacteria in the guts of mice, reports a study from Sahlgrenska Academy published in Cell Metabolism. The researchers transferred these microbes into other mice to see how they affected health. The results suggest that gut bacteria share some of the responsibility for the beneficial effects of fish oil and the harmful effects of lard.

In particular, mice that received transplants of gut microbes associated with a fish oil diet were protected against diet-induced weight gain and inflammation compared with mice transplanted with gut microbes associated with a lard diet. This demonstrates that gut microbes are an independent factor aggravating inflammation associated with diet-induced obesity and gives hope that a probiotic might help counteract a "greasy" diet.


Fish Oil-Diet Benefits May be Mediated by Gut Microbes

University of Gothenburg

Interventions for optimizing health

"We wanted to determine whether gut microbes directly contribute to the metabolic differences associated with diets rich in healthy and unhealthy fats," says first study author Robert Caesar of the University of Gothenburg. Even though the study was done in mice, "our goal is to identify interventions for optimizing metabolic health in humans."

Monitoring the metabolics

Caesar, working in the lab of senior study author Fredrik Bäckhed, began by feeding either lard or fish oil to mice for 11 weeks and monitoring signs of metabolic health.

While the consumption of lard promoted the growth of bacteria called Bilophila, which have been linked to gut inflammation, the fish oil diet increased the abundance of bacteria called Akkermansia muciniphila, known to reduce weight gain and improve glucose metabolism in mice.

"We were surprised that the lard and the fish oil diet, despite having the same energy content and the same amount of dietary fiber--which is the primary energy source for the gut bacteria--resulted in fundamentally different gut microbiota communities and that the microbiota per se had such large effects on health," says Fredrik Bäckhed.

Additional evidence

In the next set of experiments, the researchers conducted "fecal transplants" to test whether fish oil-diet microbes could improve the health of mice fed only lard and vice versa. The results provide additional evidence that gut microbe communities can both determine and recover health problems caused by poor diet.

"Our paper supports previous reports indicating the bacteria Akkermansia muciniphila is a promoter of a healthy phenotype," Bäckhed says. "However, further investigations will be needed to determine if this bacteria can be used as probiotic strain and, in that case, how it should be combined with diet to optimize health outcomes."

The paper "Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling" was published in Cell Metabolism 27 August.

Link to journal: http://www.cell.com/cell-metabolism/home

For more information please contact:

Fredrik Bäckhed, Professor at Sahlgrenska Academy, University of Gothenburg
Fredrik.Backhed@wlab.gu.se
+46 (0)31-342 7833
+46 (0)70-2182355

Robert Caesar, researcher at the Sahlgrenska Academy, University of Gothenburg
Robert.Caesar@wlab.gu.se
Phone: +46 (0)31-342 8672

Weitere Informationen:

http://www.gu.se/english/about_the_university/news-calendar/News_detail//fish-oi...

Henrik Axlid | idw - Informationsdienst Wissenschaft

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Epoxy compound gets a graphene bump

14.11.2018 | Materials Sciences

Microgel powder fights infection and helps wounds heal

14.11.2018 | Health and Medicine

How algae and carbon fibers could sustainably reduce the athmospheric carbon dioxide concentration

14.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>