A research team led by Monica Bettencourt Dias, from Instituto Gulbenkian de Ciencia (IGC, Portugal), discovered important features of cancer cells that may help clinicians fighting cancer.
The researchers observed that the number and size of tiny structures that exist inside cells, called centrioles, are increased in the most aggressive sub-types of cancer. This study will be published in Nature Communications* on the 28th of March.
Cancer is a very diverse disease with some tumours being more aggressive and more resistant to chemotherapy than others. Clinicians are eager to find novel diagnostic, prognostic and treatment tools that allow them to predict outcomes and treat patients in a more personalised way. The study now published may contribute to this process.
About 100 times smaller than the cross section of a hair, centrioles have been called the cell´s "brain", as they play crucial roles in cell multiplication, movement and communication. Their number and size are highly controlled in normal cells. Since their discovery, more than one century ago, it has been proposed that an abnormal increase in the number of these structures may induce cancer..
Bettencourt-Dias's team investigated the incidence of centriole abnormalities in human cancer cells. The researchers thoroughly analysed a panel of 60 human cancer lines originated from 9 distinct tissues. Their results reveal that cancer cells often have extra and longer centrioles, which are absent in normal cells.
Importantly, the research team observed that supernumerary centrioles are more prevalent in aggressive breast - as the triple negative - and colon cancer. Also, the team discovered that longer centrioles are excessively active, which perturbs cell division and could favour cancer formation.
"Our data confirm that deregulated number and size of centrioles inside cells is associated with malignant features. This finding may help establishing centriole properties as a way of classifying tumours in order to establish prognosis and predict treatment response", says Gaelle Marteil, first author of this study and researcher at Bettencourt-Dias laboratory.
What is the next step? "The cell lines that we analysed are already well characterized in terms of genetic changes and resistance to therapeutics. We are pursuing our studies in collaboration with Nuno Barbosa-Morais' team at Instituto de Medicina Molecular, in Lisbon, and Joana Paredes at I3S, in Porto, to explore new mechanisms and therapeutics that could target centrioles in cancer", adds Monica Bettencourt-Dias.
This study involved an international research team from Instituto Gulbenkian de Ciencia, I3S- Instituto de Investigação e Inovação em Saúde (Portugal), IPATIMUP - Instituto de Patologia e Imunologia Molecular (Portugal), Instituto de Medicina Molecular (Portugal), Instituto Portugues de Oncologia (Portugal), and Dana-Faber Cancer Institute (USA). This work was funded by European Research Council (ERC), European Molecular Biology Organization (EMBO), Fundação para a Ciencia e a Tecnologia (FCT, Portugal), and FCT- Harvard Medical School Program Portugal.
* Marteil, G., Guerrero, A., Vieira, A.F., de Almeida, B.P., Machado, P., Mendonça, S., Mesquita, M., Vilarreal, B., Fonseca, I., Francia, M.E., Dores, K., Martins, N.P., Jana, S.C., Tranfield, E.M., Barbosa-Morais, N.L., Paredes, J., Pellman, D., Godinho, S.A., Bettencourt-Dias, M. (2018) Over-elongation of Centrioles in Cancer Promotes Centriole Amplification and Chromosome Missegregation. Nature Communications. DOI: 10.1038/s41467-018-03641-x.
Ana Mena | EurekAlert!
The hidden structure of the periodic system
17.06.2019 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)
Tiny probe that senses deep in the lung set to shed light on disease
17.06.2019 | University of Edinburgh
The well-known representation of chemical elements is just one example of how objects can be arranged and classified
The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...
Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.
The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....
Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.
Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
17.06.2019 | Information Technology
17.06.2019 | Earth Sciences
17.06.2019 | Ecology, The Environment and Conservation