The researchers believe that these results are also applicable to children that have suffered damage due to radiotherapy of brain tumors.
Children that receive radiation treatment for brain tumors often develop learning and memory problems later in life that may be associated with attention deficits. These symptoms have been linked to radiation-induced damage, which not only kills cancer cells, but also stem cells that reside in the hippocampus, a region essential for proper memory function.
Dr. Andrew Naylor has previously studied the effects of physical exercise on stem cells, and Associate professor Klas Blomgren has studied the consequences of irradiation on brain cells. Together with Professor Georg Kuhn, a pioneer in the brain stem cell field, the group investigated whether physical training could counteract previously established damage to certain regions of the brain. They exposed nine-day-old mice to a radiation dose that resulted in damage to the mouse brain, similar to damage observed in human cancer patients. Half of the mice were given free access to a running wheel, which mice like to run on for extended periods of time. At 13 weeks of age, the mice were placed in an open space and were allowed to explore while their behavior was analyzed by studying a number of variables to describe their movement patterns.
The results from the study demonstrated that irradiated mice showed increased motor activity and altered movement patterns that were normalized if they were allowed to exercise. In addition, the mouse brains contained 50% more stem cells than their non-exercising counterparts. The researchers were also able to determine that newly formed nerve cells in an irradiated brain form fewer extensions, compared to a non-irradiated brain. The nerve extensions were not only fewer, but they also pointed in the wrong direction. Interestingly, if the animals were allowed to exercise, the nerve extensions were normalized. "These results suggest that irradiation-induced damage in children with brain tumors could be reduced if the child under guidance is allowed to do stimulating and fun exercise", says Professor Georg Kuhn.Journal: Proceedings of the National Academy of Sciences USA
Associate professor/pediatrician Klas Blomgren, phone: +46 31 786 3376, +46 703 233 353, e-mail: email@example.com
Ulrika Lundin | idw
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology