The researchers believe that these results are also applicable to children that have suffered damage due to radiotherapy of brain tumors.
Children that receive radiation treatment for brain tumors often develop learning and memory problems later in life that may be associated with attention deficits. These symptoms have been linked to radiation-induced damage, which not only kills cancer cells, but also stem cells that reside in the hippocampus, a region essential for proper memory function.
Dr. Andrew Naylor has previously studied the effects of physical exercise on stem cells, and Associate professor Klas Blomgren has studied the consequences of irradiation on brain cells. Together with Professor Georg Kuhn, a pioneer in the brain stem cell field, the group investigated whether physical training could counteract previously established damage to certain regions of the brain. They exposed nine-day-old mice to a radiation dose that resulted in damage to the mouse brain, similar to damage observed in human cancer patients. Half of the mice were given free access to a running wheel, which mice like to run on for extended periods of time. At 13 weeks of age, the mice were placed in an open space and were allowed to explore while their behavior was analyzed by studying a number of variables to describe their movement patterns.
The results from the study demonstrated that irradiated mice showed increased motor activity and altered movement patterns that were normalized if they were allowed to exercise. In addition, the mouse brains contained 50% more stem cells than their non-exercising counterparts. The researchers were also able to determine that newly formed nerve cells in an irradiated brain form fewer extensions, compared to a non-irradiated brain. The nerve extensions were not only fewer, but they also pointed in the wrong direction. Interestingly, if the animals were allowed to exercise, the nerve extensions were normalized. "These results suggest that irradiation-induced damage in children with brain tumors could be reduced if the child under guidance is allowed to do stimulating and fun exercise", says Professor Georg Kuhn.Journal: Proceedings of the National Academy of Sciences USA
Associate professor/pediatrician Klas Blomgren, phone: +46 31 786 3376, +46 703 233 353, e-mail: email@example.com
Ulrika Lundin | idw
Discovery of genes involved in the biosynthesis of antidepressant
09.12.2019 | Leibniz Institute of Plant Genetics and Crop Plant Research
Scientists have spotted new compounds with herbicidal potential from sea fungus
09.12.2019 | Far Eastern Federal University
Using a clever technique that causes unruly crystals of iron selenide to snap into alignment, Rice University physicists have drawn a detailed map that reveals...
University of Texas and MIT researchers create virtual UAVs that can predict vehicle health, enable autonomous decision-making
In the not too distant future, we can expect to see our skies filled with unmanned aerial vehicles (UAVs) delivering packages, maybe even people, from location...
With ultracold chemistry, researchers get a first look at exactly what happens during a chemical reaction
The coldest chemical reaction in the known universe took place in what appears to be a chaotic mess of lasers. The appearance deceives: Deep within that...
Abnormal scarring is a serious threat resulting in non-healing chronic wounds or fibrosis. Scars form when fibroblasts, a type of cell of connective tissue, reach wounded skin and deposit plugs of extracellular matrix. Until today, the question about the exact anatomical origin of these fibroblasts has not been answered. In order to find potential ways of influencing the scarring process, the team of Dr. Yuval Rinkevich, Group Leader for Regenerative Biology at the Institute of Lung Biology and Disease at Helmholtz Zentrum München, aimed to finally find an answer. As it was already known that all scars derive from a fibroblast lineage expressing the Engrailed-1 gene - a lineage not only present in skin, but also in fascia - the researchers intentionally tried to understand whether or not fascia might be the origin of fibroblasts.
Fibroblasts kit - ready to heal wounds
Research from a leading international expert on the health of the Great Lakes suggests that the growing intensity and scale of pollution from plastics poses serious risks to human health and will continue to have profound consequences on the ecosystem.
In an article published this month in the Journal of Waste Resources and Recycling, Gail Krantzberg, a professor in the Booth School of Engineering Practice...
03.12.2019 | Event News
15.11.2019 | Event News
15.11.2019 | Event News
09.12.2019 | Earth Sciences
09.12.2019 | Information Technology
09.12.2019 | Life Sciences