Cancer cells have a different DNA methylation pattern from that of healthy cells. These patterns can be used to explain tumour-specific deviations in gene expression and to identify biomarkers for the detection of tumours, as well as associated prognosis and treatment planning. This is all possible thanks to epigenetics. Epigenetics looks at special regulation mechanisms, such as DNA methylation and histone modifications, which determine the gene expression pattern of different types of cell and are passed on to daughter cells, without there being any specific changes to the DNA base sequence. Using this technology, it is now also possible to identify the original tumour cells, by comparing them with healthy cells.
In collaboration with scientists from the Austrian Institute of Technology (AIT), the University of Cambridge and the University of Southern California (USC), molecular biologist Melanie Hassler from the working group led by Gerda Egger (Department of Pathology at MedUni Vienna, Division of Experimental Pathology, Head: Lukas Kenner) has analysed the methylation pattern of Anaplastic Large Cell Lymphoma (ALCL), an aggressive non-Hodgkin lymphoma that primarily affects children and young adults. ALCL is a very aggressive form of leukaemia, which usually manifests itself as tumours in the lymph nodes, skin, lungs, liver and soft tissues.
However, in the paper that was recently published in the leading journal "Cell Reports", the researchers were able to use the methylation pattern to show that – contrary to what we previously thought – ALCL resembles early T-cell development in the thymus gland, which is part of the lymphatic system. Moreover, due to epigenetic silencing, these lymphomas lack important T-cell-specific factors for cell development and differentiation. Hassler explains: "Certain drugs that interfere in the methylation programme of cancer cells could be used in future to adjust the methylation pattern of ALCL cells to that of healthy T-cells, thereby arresting tumour growth."
A better understanding of ALCL
Egger: "The results of this study have given us a better understanding of the development of ALCL in children and adolescents, so that in future we will be able to attack cancer cells in a targeted way, using epigenetic therapies. Furthermore, decoding of the methylation pattern of ALCL provides us with a basis for establishing biomarkers in the area of personalised and translational medicine." Gerda Egger heads up the epigenetics working group at the Department of Pathology and is Deputy Director at the Ludwig Boltzmann Institute for Applied Diagnostics.
Full bibliographic information
„Insights into the pathogenesis of Anaplastic Large Cell Lymphoma through genome-wide DNA methylation profiling.“ Melanie R. Hassler, Walter Pulverer, Ranjani Lakshminarasimhan, Elisa Redl, Julia Hacker, Gavin D. Garland, Olaf Merkel, Ana-Iris Schiefer, Ingrid Simonitsch-Klupp, Lukas Kenner, Daniel J. Weisenberger, Andreas Weinhaeusel, Suzanne D. Turner and Gerda Egger, Cell Reports, 2016, 17:1-13;
Johannes Angerer | AlphaGalileo
Insect Antibiotic Provides New Way to Eliminate Bacteria
15.11.2018 | Universität Zürich
New findings help to better calculate the oceans’ contribution to climate regulation
15.11.2018 | Jacobs University Bremen gGmbH
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
15.11.2018 | Information Technology
15.11.2018 | Life Sciences
15.11.2018 | Life Sciences