One-third of all our proteins have the cell membrane as their natural environment, where they perform several of the most basic life-preserving biological processes. Approximately half of the most common drugs today are directed at membrane receptor proteins. Understanding membrane proteins is therefore vital in modern drug development.
The new biosensor is based on nanostructures which comprise holes in thin metal films where different types of membrane with membrane proteins can be formed. This makes it possible to analyse the features of the proteins, which are normally sensitive and unstable outside their natural environment. On Friday, December 12, Andreas Dahlin will defend his thesis.
"All processes which are being developed are spontaneous under the right conditions and take place 'by themselves'. The thesis also shows how biochemical reactions that take place in the membrane can be studied by measuring the colours on the nanostructured surface," he states.
The colour changes can be attributed to the local chemical environment on the nanostructured metal surface and provide information about different processes in which the proteins being studied are involved.
"Greater knowledge of the reactions in membrane proteins will lead to a greater understanding of how a drug functions, which will ultimately contribute to our ability to develop several drugs more rapidly," says Andreas Dahlin.
The colour phenomenon arises due to what are known as plasmons - heat wave movement that arises when light induces electrons to move in a fixed rhythm on a metal surface. The strong colours generated by plasmons have been utilised by people for thousands of years.
The first alchemists in China made elixir containing gold nanoparticles with a clear red colour and it was claimed that they had life-prolonging features. This type of alternative medicine exists even today. Another common example of plasmons is the clear colours found in mediaeval church windows.
A great deal of the work was carried out at the Department of Solid State Physics at Lund University. There has also been collaboration with the Department of Clinical Chemistry at Sahlgrenska University Hospital and with Duke University in Durham, USA. The results have been highlighted in the international research field and are often referred to in international journals.Contact
Sofie Hebrand | idw
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences