Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of a molecule that initiates maturation of mammalian eggs can increase IVF pregnancies

06.03.2012
Women who have eggs that cannot mature will not become pregnant, and they cannot be helped by in vitro fertilization (IVF).

Now researchers at the University of Gothenburg, Sweden, have identified a molecule called Cdk1 that has an important function for mammalian egg maturation. In the future this could lead to an increased rate of successful IVF.

Up to 15% of all women of reproductive age struggle to become pregnant. In vitro fertilization (IVF) can help these women become mothers. However, women who are infertile because their eggs do not mature properly cannot be helped medically, as immature eggs cannot be fertilized. In the future, such patients might be helped as a research group at the University of Gothenburg has found that the Cdk1 molecule has an important function in mammalian egg maturation. Their results have now been published in the journal Human Molecular Genetics.

"This is the first functional evidence that Cdk1 is a key molecule in mammalian egg maturation. If the results can be translated into clinical settings, it could possibly improve the chances of successful IVF treatment for women who today are not becoming pregnant because their eggs do not mature" says Kui Liu, professor at the Department of Chemistry and Molecular Biology, the University of Gothenburg, Sweden.

Kui Liu and his colleagues performed experiments on tissue-specific knockout mice. The results show that when the Cdk1 molecule was removed from eggs of mice, the egg maturation stopped. When the molecule was added again, maturation resumed.

Professor Liu is a professor in molecular biology at the Faculty of Science, University of Gothenburg, since February 2011. His research group specializes in studying the development of female germ cells. In the last few years he has been working on making his results useful for humans.

"We are eager to start tests on human eggs. Hopefully we can apply this in clinics within ten years" says Liu.

The article, titled Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes, was published in the journal Human Molecualar Genetics on 24 February 2012.

Read the article: http://hmg.oxfordjournals.org/cgi/reprint/dds061

IN VITRO FETILIZATION (IVF)
During IVF, eggs are taken out from the woman’s ovary. The eggs are put together with sperm in a dish containing nutrient medium. The fertilized eggs are then transferred back to the woman to develop in the uterus. The world’s first successful IVF was performed in the UK in 1978, and since then about two million children have been born through IVF. The first successful IVF in Scandinavia was performed at the Sahlgrenska University Hospital, Gothenburg, Sweden, in 1982. In Sweden about 2500 children are born through IVF every year.
More information, please contact:Kui Liu, professor
Tel: +46-73-6205064
E-mail: kui.liu@gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se
http://hmg.oxfordjournals.org/cgi/reprint/dds061

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Protein pores packed in polymers make super-efficient filtration membranes

A multidisciplinary team of engineers and scientists has developed a new class of filtration membranes for a variety of applications, from water purification to small-molecule separations to contaminant-removal processes, that are faster to produce and higher performing than current technology. This could reduce energy consumption, operational costs and production time in industrial separations.

Led by Manish Kumar, associate professor in the Cockrell School of Engineering at The University of Texas at Austin, the research team describes their new...

Im Focus: Integrate Micro Chips for electronic Skin

Researchers from Dresden and Osaka present the first fully integrated flexible electronics made of magnetic sensors and organic circuits which opens the path towards the development of electronic skin.

Human skin is a fascinating and multifunctional organ with unique properties originating from its flexible and compliant nature. It allows for interfacing with...

Im Focus: Dresden researchers discover resistance mechanism in aggressive cancer

Protease blocks guardian function against uncontrolled cell division

Researchers of the Carl Gustav Carus University Hospital Dresden at the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international...

Im Focus: New roles found for Huntington's disease protein

Crucial role in synapse formation could be new avenue toward treatment

A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative...

Im Focus: A new look at 'strange metals'

For years, a new synthesis method has been developed at TU Wien (Vienna) to unlock the secrets of "strange metals". Now a breakthrough has been achieved. The results have been published in "Science".

Superconductors allow electrical current to flow without any resistance - but only below a certain critical temperature. Many materials have to be cooled down...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

„Advanced Battery Power“- Conference, Contributions are welcome!

07.01.2020 | Event News

 
Latest News

Scientists find far higher than expected rate of underwater glacial melting

29.01.2020 | Earth Sciences

What's in your water?

29.01.2020 | Power and Electrical Engineering

Screening sweet peppers for organic farming

29.01.2020 | Agricultural and Forestry Science

VideoLinks
Science & Research
Overview of more VideoLinks >>>