Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of a molecule that initiates maturation of mammalian eggs can increase IVF pregnancies

06.03.2012
Women who have eggs that cannot mature will not become pregnant, and they cannot be helped by in vitro fertilization (IVF).

Now researchers at the University of Gothenburg, Sweden, have identified a molecule called Cdk1 that has an important function for mammalian egg maturation. In the future this could lead to an increased rate of successful IVF.

Up to 15% of all women of reproductive age struggle to become pregnant. In vitro fertilization (IVF) can help these women become mothers. However, women who are infertile because their eggs do not mature properly cannot be helped medically, as immature eggs cannot be fertilized. In the future, such patients might be helped as a research group at the University of Gothenburg has found that the Cdk1 molecule has an important function in mammalian egg maturation. Their results have now been published in the journal Human Molecular Genetics.

"This is the first functional evidence that Cdk1 is a key molecule in mammalian egg maturation. If the results can be translated into clinical settings, it could possibly improve the chances of successful IVF treatment for women who today are not becoming pregnant because their eggs do not mature" says Kui Liu, professor at the Department of Chemistry and Molecular Biology, the University of Gothenburg, Sweden.

Kui Liu and his colleagues performed experiments on tissue-specific knockout mice. The results show that when the Cdk1 molecule was removed from eggs of mice, the egg maturation stopped. When the molecule was added again, maturation resumed.

Professor Liu is a professor in molecular biology at the Faculty of Science, University of Gothenburg, since February 2011. His research group specializes in studying the development of female germ cells. In the last few years he has been working on making his results useful for humans.

"We are eager to start tests on human eggs. Hopefully we can apply this in clinics within ten years" says Liu.

The article, titled Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes, was published in the journal Human Molecualar Genetics on 24 February 2012.

Read the article: http://hmg.oxfordjournals.org/cgi/reprint/dds061

IN VITRO FETILIZATION (IVF)
During IVF, eggs are taken out from the woman’s ovary. The eggs are put together with sperm in a dish containing nutrient medium. The fertilized eggs are then transferred back to the woman to develop in the uterus. The world’s first successful IVF was performed in the UK in 1978, and since then about two million children have been born through IVF. The first successful IVF in Scandinavia was performed at the Sahlgrenska University Hospital, Gothenburg, Sweden, in 1982. In Sweden about 2500 children are born through IVF every year.
More information, please contact:Kui Liu, professor
Tel: +46-73-6205064
E-mail: kui.liu@gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se
http://hmg.oxfordjournals.org/cgi/reprint/dds061

More articles from Life Sciences:

nachricht Antibiotics: New substances break bacterial resistance
12.11.2019 | Martin-Luther-Universität Halle-Wittenberg

nachricht How the Zika virus can spread
11.11.2019 | Goethe-Universität Frankfurt am Main

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Magnets for the second dimension

If you've ever tried to put several really strong, small cube magnets right next to each other on a magnetic board, you'll know that you just can't do it. What happens is that the magnets always arrange themselves in a column sticking out vertically from the magnetic board. Moreover, it's almost impossible to join several rows of these magnets together to form a flat surface. That's because magnets are dipolar. Equal poles repel each other, with the north pole of one magnet always attaching itself to the south pole of another and vice versa. This explains why they form a column with all the magnets aligned the same way.

Now, scientists at ETH Zurich have managed to create magnetic building blocks in the shape of cubes that - for the first time ever - can be joined together to...

Im Focus: A new quantum data classification protocol brings us nearer to a future 'quantum internet'

The algorithm represents a first step in the automated learning of quantum information networks

Quantum-based communication and computation technologies promise unprecedented applications, such as unconditionally secure communications, ultra-precise...

Im Focus: Distorted Atoms

In two experiments performed at the free-electron laser FLASH in Hamburg a cooperation led by physicists from the Heidelberg Max Planck Institute for Nuclear physics (MPIK) demonstrated strongly-driven nonlinear interaction of ultrashort extreme-ultraviolet (XUV) laser pulses with atoms and ions. The powerful excitation of an electron pair in helium was found to compete with the ultrafast decay, which temporarily may even lead to population inversion. Resonant transitions in doubly charged neon ions were shifted in energy, and observed by XUV-XUV pump-probe transient absorption spectroscopy.

An international team led by physicists from the MPIK reports on new results for efficient two-electron excitations in helium driven by strong and ultrashort...

Im Focus: A Memory Effect at Single-Atom Level

An international research group has observed new quantum properties on an artificial giant atom and has now published its results in the high-ranking journal Nature Physics. The quantum system under investigation apparently has a memory - a new finding that could be used to build a quantum computer.

The research group, consisting of German, Swedish and Indian scientists, has investigated an artificial quantum system and found new properties.

Im Focus: Shedding new light on the charging of lithium-ion batteries

Exposing cathodes to light decreases charge time by a factor of two in lithium-ion batteries.

Researchers at the U.S. Department of Energy's (DOE) Argonne National Laboratory have reported a new mechanism to speed up the charging of lithium-ion...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

High entropy alloys for hot turbines and tireless metal-forming presses

05.11.2019 | Event News

Smart lasers open up new applications and are the “tool of choice” in digitalization

30.10.2019 | Event News

International Symposium on Functional Materials for Electrolysis, Fuel Cells and Metal-Air Batteries

02.10.2019 | Event News

 
Latest News

Magnets for the second dimension

12.11.2019 | Machine Engineering

New efficiency world record for organic solar modules

12.11.2019 | Power and Electrical Engineering

Non-volatile control of magnetic anisotropy through change of electric polarization

12.11.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>