Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Diagnostics for everyone

14.10.2019

Researchers from the Max Planck Institute of Colloids and Interfaces in Potsdam present a cost-effective machine for the production of microarrays. These are indispensable for the research of new vaccines.

Microarrays are state-of-the-art tools in molecular biology that enable the rapid and parallel diagnosis of various diseases. Therefore, they are indispensable for the development of new vaccines. Like a computer chip, microarrays contain a lot of information in the smallest space.


Production of a microarray with the cost-effective DIY setup. A laser from a Blu-ray player accurately transfers minute amounts of biomolecules to a surface with up to 2 500 spots per square cm².

Max Planck Institute of Colloids and Interfaces

Microarrays contain thousands of different biomolecules on a surface of a few square centimeters, which can be analyzed in a single experiment. The production of such microarrays has been very expensive and required complex machinery.

Cost-effective, laser-based method
Therefore, the research group of Felix Loeffler develops cost-effective processes and researches novel technologies for the chemical production of microarrays. Similar to the principle of a typewriter, a laser can transfer small polymer nanosheets, containing certain colors or chemical building blocks, in finely defined dot patterns.

Subsequently, these molecules can chemically react to complex artificial structures, representing, for example, parts of a pathogen. These microarrays are then used for vaccine research or blood testing. So far, however, this technique could only be used by a few specialists.

DIY microarrays

In a collaboration of the departments of "Biomolecular Systems" and "Colloid Chemistry", Eickelmann et al. present a cost-effective approach to generate microarrays and show a first application in carbohydrate research. Based on a low-cost commercial laser engraver, employing simple components of consumer electronics (Blu-ray player), they developed a very simple system.

In addition, they made a spin coater from remaining components, which serves to produce the (color) donor surfaces. Thus, all steps for microarray production can now be performed in any chemistry lab in the world without any special equipment. The total cost of this system is less than 200 euros, which is 200 times cheaper than a conventional device.

Felix Löffler, senior scientist, emphasizes: "The principle is suitable for many different applications and also offers great potential for basic research. It is suitable for the parallel development of new chemical reactions, as well as, for use in disease research, for the synthesis of proteins, sugars, and DNA."

Originalpublikation:

Stephan Eickelmann, Alexandra Tsouka, Jasmin Heidepriem, Grigori Paris, Junfang Zhang, Valerio Molinari, Marco Mende, Felix F. Loeffler:
A Low‐Cost Laser‐Based Nano‐3D Polymer Printer for Rapid Surface Patterning and Chemical Synthesis of Peptide and Glycan Microarrays
Advanced Materials Technologies(2019)

Katja Schulze | Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Further information:
http://www.mpikg.mpg.de

More articles from Life Sciences:

nachricht Lab-free infection test could eliminate guesswork for doctors
26.02.2020 | University of Southampton

nachricht MOF co-catalyst allows selectivity of branched aldehydes of up to 90%
26.02.2020 | National Centre of Competence in Research (NCCR) MARVEL

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: High-pressure scientists in Bayreuth discover promising material for information technology

Researchers at the University of Bayreuth have discovered an unusual material: When cooled down to two degrees Celsius, its crystal structure and electronic properties change abruptly and significantly. In this new state, the distances between iron atoms can be tailored with the help of light beams. This opens up intriguing possibilities for application in the field of information technology. The scientists have presented their discovery in the journal "Angewandte Chemie - International Edition". The new findings are the result of close cooperation with partnering facilities in Augsburg, Dresden, Hamburg, and Moscow.

The material is an unusual form of iron oxide with the formula Fe₅O₆. The researchers produced it at a pressure of 15 gigapascals in a high-pressure laboratory...

Im Focus: From China to the South Pole: Joining forces to solve the neutrino mass puzzle

Study by Mainz physicists indicates that the next generation of neutrino experiments may well find the answer to one of the most pressing issues in neutrino physics

Among the most exciting challenges in modern physics is the identification of the neutrino mass ordering. Physicists from the Cluster of Excellence PRISMA+ at...

Im Focus: Therapies without drugs

Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master.

A study by the Robert Koch Institute has found that one in four women will suffer from weak bladders at some point in their lives. Treatments of this condition...

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Scientists 'film' a quantum measurement

26.02.2020 | Physics and Astronomy

Melting properties determine the biological functions of the cuticular hydrocarbon layer of ants

26.02.2020 | Interdisciplinary Research

Lights, camera, action... the super-fast world of droplet dynamics

26.02.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>