Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Defect in transport system cause DNA chaos in red blood cells

13.03.2012
Within all our cells lies two meters of DNA, highly ordered in a structure of less than 10 micro meters in diameter. Special proteins called histones act as small building bricks, organising our DNA in this structure.
Preservation of the structure is necessary to maintain correct function of our genes, making histones detrimental for maintaining a healthy and functional body. The research group of Associate Professor Anja Groth from BRIC, University of Copenhagen, has just elucidated a function of the protein Codanin-1, shedding light on the rare anemic disease CDAI where development of the red blood cells is disturbed. The new results also contribute with important knowledge on how our DNA-structure is maintained and how our genes are regulated.

"We became interested in Codanin-1 as it was well-known that mutations in the gene cause CDAI, whereas the function of the protein was entirely unknown. Our new results show that Codanin-1 is detrimental for the transport of newly synthesized histones and for the ordering of our DNA, when our cells are dividing. As this function is partly defect in CDAI, we could use the disease as a model to gain important knowledge in some of the basic processes that are crucial for normal cell division and development," says Associate Professor and group leader, Anja Groth.

Loss of guard function result in defective blood cells
Our DNA is copied and each identical copy is passed on to each of the two daughter cells when our cells divide. The ordered DNA structure also needs to be copied, which demands a constant supply of new histones. The histones are transported into the nucleus of our cells, through a molecular transportation system. Here they serve as small bricks that the DNA is wrapped around in an orderly structure, guided by information carried by the histones. The new results show that codanin-1 is crucial for the regulation of the histone transport. Mutations in Codanin-1 make the protein incapable of regulating the transport, giving rise to defects in the development of the red blood cells.

"Codanin-1 appears to function as a guard, which we think can detect internal and external signals to our cells. The protein then regulates the transport of new histones to the nucleus of our cells, based on this information. This transportation mechanism is defect in patients with CDAI, and for some reason that we do not yet fully understand, does this primarily affect the red blood cells," says postdoc Zuzana Jasencakova, who has been responsible for the laboratory experiments together with Ph.D. student Katrine Ask.

Basal biology and disease research goes hand in hand
Anja Groth’s research group intensively studies the basal biological mechanisms that control our DNA-structure and thereby the activity of our genes. Accordingly, they normally work with general biological model systems, but for this project, they used the characteristic of the disease CDAI to answer some basal biological questions:

"It is mostly the other way around, that basal biological findings are used to understand the development of disease. But here, we have used the defect protein of CDAI to elucidate some basal biological mechanisms. The fact that Codanin-1 serves a detrimental role in all our cells, but that defects primarily affect the red blood cells is very interesting. Hopefully we can use this detail to gain further knowledge on how our cells maintain a correct DNA-structure and regulates the genes," says Anja Groth.

The results have just been published in EMBO Journal: ”Codanin-1, mutated in the anaemic diesease CDAI, regulates Asf1 function in S-phase histone supply” , Ask et al, EMBO March 2012.

Contact:

Associate Professor Anja Groth, BRIC
Phone: +45 35325538
Mobile: +45 30507307

Postdoc Zuzana Jasencakova, BRIC
Phone: +45 35325833

Anja Groth | EurekAlert!
Further information:
http://www.ku.dk

More articles from Life Sciences:

nachricht NUI Galway highlights reproductive flexibility in hydractinia, a Galway bay jellyfish
24.02.2020 | National University of Ireland Galway

nachricht Shaping the rings of molecules
24.02.2020 | University of Montreal

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

NUI Galway highlights reproductive flexibility in hydractinia, a Galway bay jellyfish

24.02.2020 | Life Sciences

KIST researchers develop high-capacity EV battery materials that double driving range

24.02.2020 | Materials Sciences

How earthquakes deform gravity

24.02.2020 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>