Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Deadly Chinese Mushrooms

31.01.2012
Mushroom amino acids revealed as cause of deaths in Yunnan province

Was the consumption of toxic mushrooms responsible for a series of unusual deaths in China’s Yunnan province? A team led by Ji-Kai Liu (Beijing) has now found further proof of this hypothesis. In the journal Angewandte Chemie, the researchers now present two unusual toxic amino acids that they found in extracts from the suspect mushrooms.


Over the last 30 years, more than 260 otherwise perfectly healthy people in Yunnan province in southwestern China died suddenly for no apparent reason. This phenomenon was designated as “sudden unexplained death” and mainly occurred in time- and location-related groupings in the rainy period between June and August in locations between 1800 and 2400 m above sea level.

Epidemiological studies in 2005 proposed that the collection of mushrooms may have been a risk factor; later studies lent weight to the hypothesis that consumption of a previously unknown type of mushroom, which the researchers named “Trogia venenata Zhu L. Yang” for its discoverer, was responsible for the deaths.

The scientists of the Kunming Institute of Botany and the Chinese Center for Disease Control and Prevention have now isolated and characterized three toxic compounds from the fruiting bodies of these mushroom in order to further prove their hypothesis. The compounds include one previously known amino acid, ã-guanidinobutyric acid, as well as two previously unknown and unusual toxic amino acids.

A crude extract from the mushrooms was separated by liquid chromatography and the toxic amino acids were isolated. Various spectroscopic techniques were used to identify their structures. The compounds were then synthesized in the laboratory and compared to the natural products. The two newly discovered amino acids have a terminal ethynyl group in common, a triple bond between two carbon atoms.

The toxicity of the two amino acids was confirmed in trials with mice. In addition, the scientists analyzed a blood sample from one individual who died from “sudden unexplained death” and detected one of the toxic mushroom amino acids.

All previous observations indicate that the mushroom Trogia venenata is the cause for the unexplained deaths. A campaign to warn inhabitants of Yunnan against the consumption of the toxic mushrooms has since been successful: No further cases of “sudden unexplained death” were recorded in 2010 and 2011.

About the Author
Dr Ji-Kai Liu is the Professor of Natural Products Chemitry at KIB as well as the Director of State Key Laboratory for Phytochemistry, and has been working on the medicinal chemistry of higher fungi for over 15 years. He is the recipient of National Award of China.
Author: Ji-Kai Liu, Kunming Institute of Botany (China), mailto:jkliu@mail.kib.ac.cn
Title: Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexplained Death in Yunnan Province, China

Angewandte Chemie International Edition, Permalink to the article: http://dx.doi.org/10.1002/anie.201106502

Ji-Kai Liu | Angewandte Chemie
Further information:
http://pressroom.angewandte.org.

More articles from Life Sciences:

nachricht First SARS-CoV-2 genomes in Austria openly available
03.04.2020 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

nachricht Do urban fish exhibit impaired sleep? Light pollution suppresses melatonin production in European perch
03.04.2020 | Leibniz-Institut für Gewässerökologie und Binnenfischerei (IGB)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Harnessing the rain for hydrovoltaics

Drops of water falling on or sliding over surfaces may leave behind traces of electrical charge, causing the drops to charge themselves. Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz have now begun a detailed investigation into this phenomenon that accompanies us in every-day life. They developed a method to quantify the charge generation and additionally created a theoretical model to aid understanding. According to the scientists, the observed effect could be a source of generated power and an important building block for understanding frictional electricity.

Water drops sliding over non-conducting surfaces can be found everywhere in our lives: From the dripping of a coffee machine, to a rinse in the shower, to an...

Im Focus: A sensational discovery: Traces of rainforests in West Antarctica

90 million-year-old forest soil provides unexpected evidence for exceptionally warm climate near the South Pole in the Cretaceous

An international team of researchers led by geoscientists from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) have now...

Im Focus: Blocking the Iron Transport Could Stop Tuberculosis

The bacteria that cause tuberculosis need iron to survive. Researchers at the University of Zurich have now solved the first detailed structure of the transport protein responsible for the iron supply. When the iron transport into the bacteria is inhibited, the pathogen can no longer grow. This opens novel ways to develop targeted tuberculosis drugs.

One of the most devastating pathogens that lives inside human cells is Mycobacterium tuberculosis, the bacillus that causes tuberculosis. According to the...

Im Focus: Physicist from Hannover Develops New Photon Source for Tap-proof Communication

An international team with the participation of Prof. Dr. Michael Kues from the Cluster of Excellence PhoenixD at Leibniz University Hannover has developed a new method for generating quantum-entangled photons in a spectral range of light that was previously inaccessible. The discovery can make the encryption of satellite-based communications much more secure in the future.

A 15-member research team from the UK, Germany and Japan has developed a new method for generating and detecting quantum-entangled photons at a wavelength of...

Im Focus: Junior scientists at the University of Rostock invent a funnel for light

Together with their colleagues from the University of Würzburg, physicists from the group of Professor Alexander Szameit at the University of Rostock have devised a “funnel” for photons. Their discovery was recently published in the renowned journal Science and holds great promise for novel ultra-sensitive detectors as well as innovative applications in telecommunications and information processing.

The quantum-optical properties of light and its interaction with matter has fascinated the Rostock professor Alexander Szameit since College.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

13th AKL – International Laser Technology Congress: May 4–6, 2022 in Aachen – Laser Technology Live already this year!

02.04.2020 | Event News

“4th Hybrid Materials and Structures 2020” takes place over the internet

26.03.2020 | Event News

Most significant international Learning Analytics conference will take place – fully online

23.03.2020 | Event News

 
Latest News

Capturing 3D microstructures in real time

03.04.2020 | Materials Sciences

First SARS-CoV-2 genomes in Austria openly available

03.04.2020 | Life Sciences

Do urban fish exhibit impaired sleep? Light pollution suppresses melatonin production in European perch

03.04.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>