Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Creating blood vessels on demand

03.04.2019

Researchers discover new cell population that can help in regenerative processes

When organs or tissues are damaged, new blood vessels must form as they play a vital role in bringing nutrients and eliminating waste. This is the only way for organs and tissues to resume their normal function.


A hydrogel injection affects the growth of new blood vessels.

Photo: AG Shastri

At present, the injection of growth factors or genetic material into the tissue site of interest can trigger angiogenesis, i.e. the growth of new blood vessels from pre-existing vessels. In a study published in the journal Advanced Materials, scientists from the Universities of Freiburg and Basel led by Prof. Dr. Prasad Shastri show that stable angiogenesis can be achieved by simple hydrogel injection. Due to its mechanical properties, this hydrogel resembles a blood clot.

The cells that organize into blood vessels need support from other cells for stability and blood flow regulation. The Freiburg researchers and the biomedical scientists Dr. Roberto Gianni-Barrera and Dr. Andrea Banfi from the University of Basel discovered a new population of cells of the immune system that circulate in the blood, the CD11b+ monocytes that produce the protein Piezo-1.

This is one of the so-called mechanoreceptors that are necessary for the interaction of cells in the central nervous system, as Shastri found out in an earlier study (https://www.pnas.org/content/111/45/16124).

The scientists were also able to clarify the role of the cell population of CD11b+ monocytes in the stabilization of newly formed blood vessels. On the basis of these results, they have developed a hydrogel which, due to its mechanical properties, is able to stimulate the CD11b+ monocytes to form piezo-1 so that new blood vessels develop at the desired site.

“Our study represents a paradigm shift, as it shows for the first time that a mechanically defined microenvironment is capable of recruiting a specific population of mechanosensing cells that can aid in a regenerative process,” says Shastri. The results had an effect on the treatment of peripheral vascular diseases, explains co-author Dr. Melika Sarem. “The hydrogel is a simple means to induce new and healthy vascular systems in a target tissue,” adds Dr. Aurelien Forget, who co-led the study at the University of Freiburg.

Prasad Shastri is Professor of Biofunctional Macromolecular Chemistry at the Institute for Macromolecular Chemistry and Professor of Cell Signalling Environments in the Excellence Cluster BIOSS Centre for Biological Signalling Studies and at the University of Freiburg.

Wissenschaftliche Ansprechpartner:

Prof. Dr. Prasad Shastri
Institute for Macromolecular Chemistry & BIOSS Centre for Biological Signalling Studies
Unviersity of Freiburg
Tel.: 0761/203-6271
E-Mail: prasad.shastri@makro.uni-freiburg.de

Originalpublikation:

Forget, A., Gianni-Barrera, R., Uccelli, A., Sarem, M., et al., Shastri, V. P. (2019): Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1+ Population of Circulating CD11b+/CD115+ Monocytes. In: Advanced Materials. DOI: 10.1002/adma.201808050

Weitere Informationen:

https://www.pr.uni-freiburg.de/pm-en/press-releases-2019/creating-blood-vessels-...

Nicolas Scherger | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht How much nature is lost due to higher yields?
10.04.2019 | Helmholtz Centre for Environmental Research - UFZ

nachricht Targeted approach to therapy for rare type of bone cancer
09.04.2019 | Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

Im Focus: Newly discovered mechanism of plant hormone auxin acts the opposite way

Auxin accumulation at the inner bend of seedling leads to growth inhibition rather than stimulation as in other plant tissues.

Increased levels of the hormone auxin usually promote cell growth in various plant tissues. Chinese scientists together with researchers from the Institute of...

Im Focus: Creating blood vessels on demand

Researchers discover new cell population that can help in regenerative processes

When organs or tissues are damaged, new blood vessels must form as they play a vital role in bringing nutrients and eliminating waste. This is the only way for...

Im Focus: Substantial differences between the tumor-promoting enzymes USP25 and USP28 identified

Researchers from the Rudolf Virchow Center of the University of Würzburg (JMU) have solved the structures of the cancer-promoting enzymes USP25 and USP28 and identified significant differences in their activities. Both enzymes promote the growth of various tumors. The results were published in the journal Molecular Cell and could benefit towards the development of new, low-side-effects anticancer drugs.

The permanent interplay of protein production and degradation is a major driver of cellular metabolism. A key mechanism of this regulation is the labeling of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

European Geosciences Union meeting: ExoMars press conference, live streams, on-site registration

02.04.2019 | Event News

Networks make it easier

02.04.2019 | Event News

 
Latest News

A Jetsons future? Assessing the role of flying cars in sustainable mobility

10.04.2019 | Automotive Engineering

Measurement of semiconductor material quality is now 100,000 times more sensitive

10.04.2019 | Power and Electrical Engineering

Are you still charging?

10.04.2019 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>