Researchers discover new cell population that can help in regenerative processes
When organs or tissues are damaged, new blood vessels must form as they play a vital role in bringing nutrients and eliminating waste. This is the only way for organs and tissues to resume their normal function.
At present, the injection of growth factors or genetic material into the tissue site of interest can trigger angiogenesis, i.e. the growth of new blood vessels from pre-existing vessels. In a study published in the journal Advanced Materials, scientists from the Universities of Freiburg and Basel led by Prof. Dr. Prasad Shastri show that stable angiogenesis can be achieved by simple hydrogel injection. Due to its mechanical properties, this hydrogel resembles a blood clot.
The cells that organize into blood vessels need support from other cells for stability and blood flow regulation. The Freiburg researchers and the biomedical scientists Dr. Roberto Gianni-Barrera and Dr. Andrea Banfi from the University of Basel discovered a new population of cells of the immune system that circulate in the blood, the CD11b+ monocytes that produce the protein Piezo-1.
This is one of the so-called mechanoreceptors that are necessary for the interaction of cells in the central nervous system, as Shastri found out in an earlier study (https://www.pnas.org/content/111/45/16124).
The scientists were also able to clarify the role of the cell population of CD11b+ monocytes in the stabilization of newly formed blood vessels. On the basis of these results, they have developed a hydrogel which, due to its mechanical properties, is able to stimulate the CD11b+ monocytes to form piezo-1 so that new blood vessels develop at the desired site.
“Our study represents a paradigm shift, as it shows for the first time that a mechanically defined microenvironment is capable of recruiting a specific population of mechanosensing cells that can aid in a regenerative process,” says Shastri. The results had an effect on the treatment of peripheral vascular diseases, explains co-author Dr. Melika Sarem. “The hydrogel is a simple means to induce new and healthy vascular systems in a target tissue,” adds Dr. Aurelien Forget, who co-led the study at the University of Freiburg.
Prasad Shastri is Professor of Biofunctional Macromolecular Chemistry at the Institute for Macromolecular Chemistry and Professor of Cell Signalling Environments in the Excellence Cluster BIOSS Centre for Biological Signalling Studies and at the University of Freiburg.
Prof. Dr. Prasad Shastri
Institute for Macromolecular Chemistry & BIOSS Centre for Biological Signalling Studies
Unviersity of Freiburg
Forget, A., Gianni-Barrera, R., Uccelli, A., Sarem, M., et al., Shastri, V. P. (2019): Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1+ Population of Circulating CD11b+/CD115+ Monocytes. In: Advanced Materials. DOI: 10.1002/adma.201808050
Nicolas Scherger | idw - Informationsdienst Wissenschaft
'Flamenco dancing' molecule could lead to better-protecting sunscreen
18.10.2019 | University of Warwick
Synthetic cells make long-distance calls
17.10.2019 | Rice University
A very special kind of light is emitted by tungsten diselenide layers. The reason for this has been unclear. Now an explanation has been found at TU Wien (Vienna)
It is an exotic phenomenon that nobody was able to explain for years: when energy is supplied to a thin layer of the material tungsten diselenide, it begins to...
Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have explored the initial consequences of the interaction of light with molecules on the surface of nanoscopic aerosols.
The nanocosmos is constantly in motion. All natural processes are ultimately determined by the interplay between radiation and matter. Light strikes particles...
Particles that are mere nanometers in size are at the forefront of scientific research today. They come in many different shapes: rods, spheres, cubes, vesicles, S-shaped worms and even donut-like rings. What makes them worthy of scientific study is that, being so tiny, they exhibit quantum mechanical properties not possible with larger objects.
Researchers at the Center for Nanoscale Materials (CNM), a U.S. Department of Energy (DOE) Office of Science User Facility located at DOE's Argonne National...
A new research project at the TH Mittelhessen focusses on the development of a novel light weight design concept for leisure boats and yachts. Professor Stephan Marzi from the THM Institute of Mechanics and Materials collaborates with Krake Catamarane, which is a shipyard located in Apolda, Thuringia.
The project is set up in an international cooperation with Professor Anders Biel from Karlstad University in Sweden and the Swedish company Lamera from...
Superconductivity has fascinated scientists for many years since it offers the potential to revolutionize current technologies. Materials only become superconductors - meaning that electrons can travel in them with no resistance - at very low temperatures. These days, this unique zero resistance superconductivity is commonly found in a number of technologies, such as magnetic resonance imaging (MRI).
Future technologies, however, will harness the total synchrony of electronic behavior in superconductors - a property called the phase. There is currently a...
02.10.2019 | Event News
02.10.2019 | Event News
19.09.2019 | Event News
18.10.2019 | Power and Electrical Engineering
18.10.2019 | Medical Engineering
18.10.2019 | Physics and Astronomy