Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Combating Secondary Infections in Clinics

04.08.2008
Just dive in: natural product hybrid provides antimicrobial and cell-resistant surfaces

Infections following treatment in clinics, retirement homes, and long-term care facilities are a grave problem for patients, and resistant germs can be particularly devastating.

“High infection rates are in particular observed related to implants, catheters, and stents,” reports Karl Gademann, “those for urinary catheters mounting up to 30 % per week!” In cooperation with his team at the Swiss Federal Institute of Technology in Lausanne, he has developed a process for coating surfaces with an antimicrobial layer. As reported in the journal Angewandte Chemie, their system is based on hybrid molecules derived from various natural products.

For a patient, the results are particularly grave if an infection occurs in an implant. Usually, replacement of the affected part is the only possible treatment. “One particularly attractive approach is the application of antibiotics directly on the material,” says Gademann. To test their idea, the team from Lausanne chose to use natural product hybrids: biologically active fragments of various natural products are coupled to combine two different modes of action.

... more about:
»HYBRID »Implant

The hybrid produced by Gademann’s team is made of three parts: two natural products are coupled by means of a polymer bridge. The first substance is anachelin, an iron transporter (siderophore) from cyanobacteria. Anachelin strongly and selectively binds metal oxides. The majority of implants are made from a metal oxide: highly biocompatible titanium dioxide. Anachelin fixes the hybrid firmly to the surface of the implant. The second natural product is the antibiotic vancomycin, which disrupts the biosynthesis of cell walls and thus stops bacterial growth. The coupling component is polyethylene glycol, a chemically inert, nontoxic polymer. It also assures that dead bacteria and cell components cannot bind to the surface.

The hybrid can be applied to titanium dioxide components in a simple dunking procedure. “We were able to demonstrate that our hybrid firmly attaches to titanium dioxide surfaces and effectively hinders infection with Bacillus subtilis as well as the attachment of cellular material,” says Gademann.

| Angewandte Chemie International
Further information:
http://www.wiley-vch.de

Further reports about: HYBRID Implant

More articles from Life Sciences:

nachricht World’s Largest Study on Allergic Rhinitis Reveals new Risk Genes
17.07.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Plant mothers talk to their embryos via the hormone auxin
17.07.2018 | Institute of Science and Technology Austria

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Microscopic trampoline may help create networks of quantum computers

17.07.2018 | Information Technology

In borophene, boundaries are no barrier

17.07.2018 | Materials Sciences

The role of Sodium for the Enhancement of Solar Cells

17.07.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>