Cleveland Clinic researchers have discovered that a naturally occurring molecule may play a role in preventing plaque buildup inside arteries, possibly leading to new plaque-fighting drugs and improved screening of patients at risk of developing atherosclerosis.
Sometimes called hardening or clogging of the arteries, atherosclerosis is the buildup of cholesterol, fatty cells, and inflammatory deposits on the inner walls of the arteries, restricting blood flow to the heart. The disease can affect the arteries in the heart, legs, brain, kidneys, and other organs, and is the most common cause heart attacks, strokes, and peripheral vascular disease.
At the cellular level, plaque buildup is the result of macrophages in the vessel wall absorbing, processing, and storing cholesterol (lipids) and then accumulating in large amounts, eventually leading to the development of arterial lesions. The researchers, led by Eugene Podrez, M.D., Ph.D., of the Department of Molecular Cardiology at Cleveland Clinic's Lerner Research Institute, have discovered that the naturally occurring molecule Akt3 regulates lipid entry into macrophages and prevents the cells from storing excessive amounts of cholesterol and collecting in the artery.
Podrez says the discovery could lead to new drugs designed to prevent atherosclerosis. It could also help doctors develop screening tests to determine patient risk level for developing the disease.
Podrez and his colleagues are now looking into the particular mechanisms behind Akt3's role in regulating lipid processing and will attempt to replicate their results in humans.
Their study, "Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice," was published in the June 6 issue of Cell Metabolism.
Wyatt DuBois | EurekAlert!
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences