Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The last checkpoint to T cell fate

05.07.2010
A research team in Japan has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell lineages to the activity of a single gene encoding a transcription factor. Reported in Science this week, the discovery lends support to a new model for the development of blood cells lineages.

While varying widely in function, all blood cells share a common origin in progenitors known as hematopoietic stem cells (HSC). In textbook theory, HSCs branch early on into two progenitor cell types, one of which, known as the common lymphoid progenitor (CLP), later differentiates into T and B cells. According to this model, T and B cells lose the potential to develop into non-lymphocytes (myeloid cells) once they pass the CLP branching point.

In a model put forth nearly ten years ago, the researchers proposed a radically different picture in which progenitor cells retain the potential to generate myeloid cells across all branches of development. In the current research, the researchers sought to substantiate this theory by pinpointing the moment at which T cell progenitors lose the potential to develop into myeloid cells, a key step in determining cell fate.

In experiments with mouse HSCs cultured on immobilized delta-like 4 proteins, the researchers found that progenitors developing toward T cells were arrested in the absence of so-called feeder cells, which support survival and growth. The arrested cells then entered a cycle of self-renewal in which they replicated but did not further develop. Testing of various conditions revealed that reduction of the cytokine interleukin-7 (IL-7), possibly corresponding to an environmental signal in the thymus, triggered resumption of development and differentiation into T cells.

... more about:
»B cells »Bcl11b »CLP »HSC »IL-7 »T cells »blood cell »cell type

Placing the final piece in the puzzle, the researchers discovered that T cell progenitors in the thymus from mice deficient in the gene Bcl11b exhibited the same halted development and self-renewal cycle, while further experiments connected up-regulation of the transcription factor encoded by this gene to IL-7 levels. Together, the findings identify Bcl11b as a “master gene” governing the final step toward differentiation into T cells, confirming the proposed model and heralding a paradigm shift in our understanding of blood cell lineages.

For more information, please contact:

Dr. Hiroshi Kawamoto
Laboratory for Lymphocyte Development
RIKEN Research Center for Allergy and Immunology (RCAI)
Tel: +81-(0)45-503-7010 / Fax: +81-(0)45-503-7009
Ms. Tomoko Ikawa (PI officer)
Global Relations Office
RIKEN
Tel: +81-(0)48-462-1225 / Fax: +81-(0)48-462-4715
Email: koho@riken.jp

gro-pr | Research asia research news
Further information:
http://www.riken.jp
http://www.researchsea.com

Further reports about: B cells Bcl11b CLP HSC IL-7 T cells blood cell cell type

More articles from Life Sciences:

nachricht Seeing on the Quick: New Insights into Active Vision in the Brain
15.08.2018 | Eberhard Karls Universität Tübingen

nachricht New Approach to Treating Chronic Itch
15.08.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>