The study, directed by the center’s director Giulio Superti-Furga, appears today in the online advanced publication route of the journal Nature Immunology. The newly discovered protein, termed AIM2, patrols the inside of human immune cells and when it encounters a DNA that is suspicious, possibly coming from an intruding virus or bacterium, triggers the secretion of the signaling protein Interleukin-1.
This proinflammatory molecule activates an anti-invasion alarm program throughout the entire body. It is one of the main causes of fever and a central mediator of autoimmune disease. Thus, the study identified a new centerpiece of the human’s defense arsenal against pathogens.
“We are excited about this molecule as it helps understand the body’s immediate reaction to infections. It is much too early to say, but in the future AIM2 could lead to ways to enhance the patients’ own protection when this is needed, as during epidemics or when otherwise immune depressed”, stresses Tilmann Bürckstümmer, the first author of the study.
The results derived from a large scale, systematic search for human proteins that bind pathogenic molecules. Three other groups from Worcester, Philadelphia and Adelaide report the identification of the same protein in parallel publications appearing in the journals Nature and Science. This fact stresses the importance of the discovery made at CeMM.
“I am very proud that our new research center could contribute to such a fundamental immunology finding. It shows that CeMM as an Austrian research organization competes in the top-league of international research only a few years after being founded and before entering its new building. We are eager to collaborate with our clinical partners at the Medical University of Vienna to investigate if malfunction of the protein may be associated with autoimmune disease, when too much inflammatory signals are produced”, adds Giulio Superti-Furga.
Good preparation is half the digestion
15.11.2018 | Max-Planck-Institut für Stoffwechselforschung
How the gut ‘talks’ to brown fat
16.11.2018 | Technische Universität München
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Physics and Astronomy
16.11.2018 | Physics and Astronomy
16.11.2018 | Life Sciences