G proteins play a central role in cellular signal processing. They are described as molecular switches that oscillate between ‘on’ and ‘off’, regulated by effectors. Biochemists at Heidelberg University have now gained fundamental insights into the mechanics of these switches.
The G protein FlhF, together with a signal sequence binding protein (SRP54) and its receptor (FtsY), constitutes the ancient family of SRP-GTPases, which consists solely of these three proteins and is responsible for the transport of proteins in or through a biological membrane. In all known organisms, SRP54 and FtsY regulate the transport of proteins using the signal recognition particle (SRP). Although the SRP system is already well understood, it was recently demonstrated that the protein SRP54 and the receptor FtsY interact with the SRP RNA in a way reminiscent of FlhF and its newly discovered effector.
“Our study of the G protein FlhF not only offers an explanation for the FlhF effector complex, it also integrates this knowledge into a general concept of SRP-GTPase activation through RNA or proteins”, says Dr. Gert Bange of the Heidelberg University Biochemistry Center. “We used FlhF to demonstrate how the ‘modern’ protein world replaced the original RNA world by means of a strikingly simple modification.” The results of the research were published in “Nature Structural & Molecular Biology”.Original publication:
Marietta Fuhrmann-Koch | idw
3D technology lets us look into the distant past
20.05.2019 | Eberhard Karls Universität Tübingen
Dangerous pathogens use this sophisticated machinery to infect hosts
20.05.2019 | California Institute of Technology
Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...
With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.
Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...
'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.
However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...
Working group led by physicist Professor Ulrich Nowak at the University of Konstanz, in collaboration with a team of physicists from Johannes Gutenberg University Mainz, demonstrates how skyrmions can be used for the computer concepts of the future
When it comes to performing a calculation destined to arrive at an exact result, humans are hopelessly inferior to the computer. In other areas, humans are...
Scientists develop a molecular recording tool that enables in vivo lineage tracing of embryonic cells
The beginning of new life starts with a fascinating process: A single cell gives rise to progenitor cells that eventually differentiate into the three germ...
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
20.05.2019 | Materials Sciences
20.05.2019 | Life Sciences
20.05.2019 | Power and Electrical Engineering