Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cells migrate collectively by intermittent bursts of activity

30.09.2016

Cell migration is a central process in the development and maintenance of multicellular organisms. Researchers of Aalto University and their research partners have now discovered that this motion occurs by intermittent bursts of activity. It can be described by universal scaling laws similar to the ones observed in other driven systems outside of biology.

When you have got a wound and it starts healing, cells start to migrate in your body to the wound. They are driven by active internal forces to invade the available space. Cell migration doesn't only take place when you are getting better. In cancer invasion cells also migrate collectively.


This is how cells are migrating. He-La cells - the oldest and most commonly used human cell line - on collagen substrate: time evolution of the front superimposed on the first frame of experiment. Credit: Oleksandr Chepizhko / Aalto University

Tissue formation during embryonic development requires the orchestrated movement of cells to specific locations. In general, cell migration is a central process in the development and maintenance of multicellular organisms.

Researchers of Aalto University and their research partners have now discovered that this motion occurs by intermittent bursts of activity. It can be described by universal scaling laws similar to the ones observed in other driven systems outside of biology.

- Our results demonstrate that living systems display universal non-equilibrium critical fluctuations, induced by cell mutual interactions, that are usually associated to externally driven inanimate media, says Oleksandr Chepizhko, Postdoctoral Researcher at Aalto University.

Researchers substantiated the analogy between collective cell migration and depinning by revealing and characterizing widely distributed bursts of activity in the collective migration of different types cells over different substrates and experimental conditions.

After that, they compared the experiments with simulations of a computational model of active particles. They found that in all these cases the statistical properties of the bursts follow universal scaling laws that are quantitatively similar to those observed in driven disordered systems.

Errors during cell migration may have serious consequences. For instance, errors may cause vascular disease, intellectual disability, metastasis or tumor formation. Increased understanding of the mechanism by which cells migrate may lead to the development of new therapeutic strategies for controlling, for example, invasive tumour cells.

Full bibliographic information

Oleksandr Chepizhko et al.: Bursts of activity in collective cell migration. PNAS 2016. DOI 10.1073/pnas.0709640104

Notes for editors

For more information:
Mikko Alava
Professor, Department of Applied Physics, School of Science, Aalto University
mikko.alava@aalto.fi
https://people.aalto.fi/new/mikko.alava

Tweet: Cells migrate collectively by intermittent bursts of activity @aaltouniversity DOI 10.1073/pnas.0709640104

Visa Noronen | AlphaGalileo

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Superconducting vortices quantize ordinary metal

Russian researchers together with their French colleagues discovered that a genuine feature of superconductors -- quantum Abrikosov vortices of supercurrent -- can also exist in an ordinary nonsuperconducting metal put into contact with a superconductor. The observation of these vortices provides direct evidence of induced quantum coherence. The pioneering experimental observation was supported by a first-ever numerical model that describes the induced vortices in finer detail.

These fundamental results, published in the journal Nature Communications, enable a better understanding and description of the processes occurring at the...

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Rapid water formation in diffuse interstellar clouds

25.06.2018 | Physics and Astronomy

Using tree-fall patterns to calculate tornado wind speed

25.06.2018 | Earth Sciences

'Stealth' material hides hot objects from infrared eyes

25.06.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>