Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer detection with sugar molecules

15.08.2017

Scientists from the University of Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner.

Galectins are a family of proteins that have become a promising source of cancer research in recent years. A representative thereof is galectin-1.


Like a spaceship, the complex sugar molecule (coloured) lands exactly on the tumor protein galectin-1, which here looks like a meteorite and is shown in black and white.

Picture: Workgroup Seibel, VCH-Wiley

It sits on the surface of all human cells; on tumor cells, however, it occurs in enormous quantities. This makes it an interesting target for diagnostics and therapy.

"Among other things, it is known that galectin-1 hides the tumor cells from the immune system," explains Professor Jürgen Seibel of the Institute of Organic Chemistry at the Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany.

Recent studies have shown that when Galectin-1 is blocked, the immune system can recognize the tumor and attack it with T cells.

Sugar molecule with docking station

No wonder, therefore, that galectin-1 has become a major focus of research. Seibel and his colleague Dr. Clemens Grimm is interested in a very specific section of this protein, the so-called carbohydrate recognition domain. They have now designed a complex sugar molecule that fits perfectly into this domain, as the scientists report in journal "ChemBioChem".

"We have equipped the sugar molecule with a docking site, for example, to connect it with a fluorescent dye or an drug," says Seibel. In addition, the scientists have described the binding of their molecule to galectin-1 with high-resolution X-ray structure analyzes.
"Our findings can serve the development of high-affinity ligands of the protein Galectin-1 and thus of new drugs," said Clemens Grimm.

Quick test for Galectin-1 in progress

Now the JMU scientists are working on a rapid test for the detection of galectin-1. It is designed to enable early detection of tumors such as neuroblastoma. For the future, Seibel's team would like to expand the sugar molecules into a kind of shuttle system that allows pharmaceutical agents to be transported directly to the tumors.

“Exploring the Structural Space of the Galectin-1–Ligand Interaction”, Nadja Bertleff-Zieschang, Julian Bechold, Clemens Grimm, Michael Reutlinger, Petra Schneider, Gisbert Schneider, Jürgen Seibel, ChemBioChem, 4. August 2017, DOI: 10.1002/cbic.201700251

Contact

Prof. Dr. Jürgen Seibel, Institute of Organic Chemistry, JMU, T +49 931 31-85326, seibel@chemie.uni-wuerzburg.de

Dr. Clemens Grimm, Institute of Organic Chemistry, JMU, T +49 931 31-84031, Clemens.Grimm@biozentrum.uni-wuerzburg.de

Robert Emmerich | Julius-Maximilians-Universität Würzburg
Further information:
http://www.uni-wuerzburg.de

More articles from Life Sciences:

nachricht A new view of microscopic interactions
01.07.2020 | University of Missouri-Columbia

nachricht Microscope allows gentle, continuous imaging of light-sensitive corals
01.07.2020 | Marine Biological Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: ILA Goes Digital – Automation & Production Technology for Adaptable Aircraft Production

Live event – July 1, 2020 - 11:00 to 11:45 (CET)
"Automation in Aerospace Industry @ Fraunhofer IFAM"

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM l Stade is presenting its forward-looking R&D portfolio for the first time at...

Im Focus: AI monitoring of laser welding processes - X-ray vision and eavesdropping ensure quality

With an X-ray experiment at the European Synchrotron ESRF in Grenoble (France), Empa researchers were able to demonstrate how well their real-time acoustic monitoring of laser weld seams works. With almost 90 percent reliability, they detected the formation of unwanted pores that impair the quality of weld seams. Thanks to a special evaluation method based on artificial intelligence (AI), the detection process is completed in just 70 milliseconds.

Laser welding is a process suitable for joining metals and thermoplastics. It has become particularly well established in highly automated production, for...

Im Focus: A structural light switch for magnetism

A research team from the Max Planck Institute for the Structure of Dynamics (MPSD) and the University of Oxford has managed to drive a prototypical antiferromagnet into a new magnetic state using terahertz frequency light. Their groundbreaking method produced an effect orders of magnitude larger than previously achieved, and on ultrafast time scales. The team’s work has just been published in Nature Physics.

Magnetic materials have been a mainstay in computing technology due to their ability to permanently store information in their magnetic state. Current...

Im Focus: Virtually Captured

Biomechanical analyses and computer simulations reveal the Venus flytrap snapping mechanisms

The Venus flytrap (Dionaea muscipula) takes only 100 milliseconds to trap its prey. Once their leaves, which have been transformed into snap traps, have...

Im Focus: NASA observes large Saharan dust plume over Atlantic ocean

NASA-NOAA's Suomi NPP satellite observed a huge Saharan dust plume streaming over the North Atlantic Ocean, beginning on June 13. Satellite data showed the dust had spread over 2,000 miles.

At NASA's Goddard Space Flight Center in Greenbelt, Maryland, Colin Seftor, an atmospheric scientist, created an animation of the dust and aerosols from the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

First exposed planetary core discovered

01.07.2020 | Physics and Astronomy

Energy-saving servers: Data storage 2.0

01.07.2020 | Power and Electrical Engineering

Laser takes pictures of electrons in crystals

01.07.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>