Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Canadian researchers first worldwide to generate pluripotent stem cells from horses

28.02.2011
Discovery opens avenue for research into new veterinary and human treatments for a range of degenerative conditions

In a world first, pluripotent stem cells have been generated from horses by a team of researchers led by Dr. Andras Nagy at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Dr. Lawrence Smith at the University of Montreal's Faculty of Veterinary Science.

The findings will help enable new stem-cell based regenerative therapies in veterinary medicine, and because horses' muscle and tendon systems are similar to our own, aid the development of preclinical models leading to human applications. The study was published in the February 28 issue of the leading journal Stem Cell Reviews and Reports.

These induced pluripotent stem (iPS) cells can develop into most other cell types and are a source of great hope for use in regenerative medicine and the development of new drugs to prevent and treat various illnesses. One aspect of regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to damage or disease. "To date, iPS cells have been established from several species, but our study is the first to report the derivation of these changeable cells from horses," Dr. Smith explained.

The research represents a breakthrough for both human and animal health alike. "Equine iPS cells bring new therapeutic potential to the veterinary field, and open up the opportunity to validate stem-cell based therapies before clinical studies in humans," Dr. Nagy said. "As well, stem-cell based studies using the horse as a model more closely replicate human illnesses, when compared with studies in mice."

After two months of reprogramming equine somatic cells, the resulting iPS cell lines expressed hallmark markers of pluripotency, contained a correct set of horse chromosomes, and were able to form a full spectrum of cell types and tissues fulfilling the criteria of pluripotency. The term pluripotency refers to the ability of a stem cell to become any of the vast number of different cell types found in the body. "This means that the cell lines passed all the tests available to us for determining if they truly are what we think they are: pluripotent and a good source for future regenerative applications," said Kristina Nagy, research associate in the Nagy laboratory and lead author of the study.

"The horse is an excellent model for a range of human degenerative diseases, especially those involving joints, bones, tendons and ligaments, such as arthritis," said Dr. Sheila Laverty, a professor in the Faculty of Veterinary Medicine at the University of Montreal. "Bone fracture, as well as damaged cartilage, tendons and ligaments heal poorly in horses. Therefore, the use of iPS cells in these animals may help enhance long-term tissue repair." Further research will be required to develop clinical treatments.

Dr. Andras Nagy is a senior investigator at the Lunenfeld, the Canada Research Chair in Stem Cells and Regeneration and McEwen investigator. He received support from the Canadian Stem Cell Network of Canada for this research. Dr. Smith is the Canadian Research Chair in Animal Cloning and Stem Cells and received support from the Canadian Arthritis Network. His lab plays a key role in the University of Montreal's Animal Reproduction Research Centre.

William Raillant-Clark | EurekAlert!
Further information:
http://www.umontreal.ca

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>