Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

BUSM researcher finds link between brain signaling and renal function

05.06.2012
Boston University School of Medicine (BUSM) researchers recently uncovered a brain signaling pathway responsible for regulating the renal excretion of sodium. The findings appear in the Journal of the Federation of American Societies for Experimental Biology.

Hypertension, or chronic high blood pressure, affects one-third of adults, significantly increasing cardiovascular risk and mortality. Approximately 50 percent of hypertensive patients are salt-sensitive and exhibit an increase in blood pressure following salt-intake.

According to the researchers, little is known about the mechanisms acting in the brain to control the removal of dietary salt from the body through the kidneys. "Our data shows that changes in dietary sodium intake evoked natural site-specific changes in brain hypothalamic paraventricular nucleus (PVN) Gái2 protein levels," said Senior Author Richard Wainford, PhD, assistant professor of pharmacology and experimental therapeutics.

Wainford and his team explored the role of Gái2 signal transduction proteins in the brain pathways activated to regulate salt and water excretion and subsequently blood pressure. They identified a previously unknown role of PVN Gái2-subunit proteins as a central mechanism mediating the suppression of renal sympathetic nerve traffic to the kidneys and the renal excretion of sodium.

These data provide a target for new therapies that may improve cardiovascular and renal excretory function. This may help treat multiple disease states, such as salt-sensitive hypertension and congestive heart failure caused by elevated sodium intake.

This research was funded by the American Heart Association (AHA) and the National Heart Lung and Blood Institute (NHLBI).

Gina Orlando | EurekAlert!
Further information:
http://www.bmc.org

More articles from Life Sciences:

nachricht Researchers find new mutation in the leptin gene
24.06.2019 | Texas Biomedical Research Institute

nachricht Straight to the heart
24.06.2019 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fraunhofer IDMT demonstrates its method for acoustic quality inspection at »Sensor+Test 2019« in Nürnberg

From June 25th to 27th 2019, the Fraunhofer Institute for Digital Media Technology IDMT in Ilmenau (Germany) will be presenting a new solution for acoustic quality inspection allowing contact-free, non-destructive testing of manufactured parts and components. The method which has reached Technology Readiness Level 6 already, is currently being successfully tested in practical use together with a number of industrial partners.

Reducing machine downtime, manufacturing defects, and excessive scrap

Im Focus: Successfully Tested in Praxis: Bidirectional Sensor Technology Optimizes Laser Material Deposition

The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.

Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on UV LED Technologies & Applications – ICULTA 2020 | Call for Abstracts

24.06.2019 | Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

 
Latest News

2nd International Conference on UV LED Technologies & Applications – ICULTA 2020 | Call for Abstracts

24.06.2019 | Event News

'Sneezing' plants contribute to disease proliferation

24.06.2019 | Agricultural and Forestry Science

Researchers find new mutation in the leptin gene

24.06.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>