Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breakthrough in regulating fat metabolism - Body’s fat switch discovered

09.12.2011
Scientists at Warwick Medical School have made an important discovery about the mechanism controlling the body’s ‘fat switch’, shedding new light on our understanding of how proteins regulate appetite control and insulin secretion.

This research, led by Professor Victor Zammit, Head of Metabolic and Vascular Health at Warwick Medical School, found that the enzyme known as ‘Carnitine palmitoyltransferase 1A’ (CPT1) has a switch which is thrown depending on the composition and curvature of its cellular membrane. This is the first time such a mechanism has been described and may possibly be unique, reflecting the importance of this protein to cellular function.

CPT1 is the key protein that regulates fatty acid oxidation in the liver and is critical for metabolism. Its activity determines whether individuals suffer from fatty liver in one extreme or ketosis in the other.

Professor Zammit explained: “Knowing that the CPT1 enzyme can switch and what controls it will ultimately lead to a better understanding of why some people appear to have a speedy metabolism and others struggle to curb their appetite.

“We are making great inroads to understanding the science behind our metabolism and how at cellular level it changes according to the influence of different factors – be they nutritional or hormonal.”

The importance of this work on clinical practice is that, having discovered the molecular mechanism, it should now be possible to design drugs that flick the switch of CPT1 in one way or the other, depending on the requirements of individual patients and the tissue that needs to be affected. For example, drugs can be developed for patients suffering from diabetic keto acidosis, a condition when insufficient insulin caused the body to start breaking down fat, so that the enzyme is inhibited to oxidize fewer fatty acids.

“This would be a major breakthrough in tackling the obesity crisis we now face,” added Professor Zammit.

The research, conducted in association with the University of Southern California, Los Angeles, USA has been published in Journal of Biological Chemistry as ‘Paper of the Week’ and the editors considered it to be within the top one percent in terms of significance both to fundamental science and potential clinical importance.

Link to paper: http://www.jbc.org/content/current ref: J. Biol. Chem. 2011 286: e99981. doi:10.1074/jbc.P111.306951

For further information or to arrange interviews, contact Kate Cox, Communications Manager on +44 (0)2476 574255/150483, m: +44(0)7920 531221 or kate.cox@warwick.ac.uk

Kate Cox | EurekAlert!
Further information:
http://www.warwick.ac.uk

More articles from Life Sciences:

nachricht Superresolution live-cell imaging provides unexpected insights into the dynamic structure of mitochondria
18.02.2020 | Heinrich-Heine-Universität Düsseldorf

nachricht Blood and sweat: Wearable medical sensors will get major sensitivity boost
18.02.2020 | Moscow Institute of Physics and Technology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

Im Focus: Quantum fluctuations sustain the record superconductor

Superconductivity approaching room temperature may be possible in hydrogen-rich compounds at much lower pressures than previously expected

Reaching room-temperature superconductivity is one of the biggest dreams in physics. Its discovery would bring a technological revolution by providing...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Movement of a liquid droplet generates over 5 volts of electricity

18.02.2020 | Power and Electrical Engineering

Powering the future: Smallest all-digital circuit opens doors to 5 nm next-gen semiconductor

18.02.2020 | Information Technology

Studying electrons, bridging two realms of physics: connecting solids and soft matter

18.02.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>